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Literature summary for 2.4.2.64 extracted from
- Characterization of the human tRNA-guanine transglycosylase: Confirmation of the heterodimeric subunit structure (2010), RNA, 16, 958-968.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | QTRT1 subunit is responsible for the transglycosylase activity. Transglycosylase activity of QTRT1 is only observed when QTRT1 and QTRTD1 are coexpressed and copurified | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| hQTRT1 and ubiquitin-specific protease 14 (USP14) coexpressed in Escherichia coli | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9BXR0 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [tRNATyr]queuine + guanine | human TGT is composed of a catalytic subunit, QTRT1, and QTRTD1, not USP14. QTRTD1 is the salvage enzyme that generates free queuine from QMP | Homo sapiens | [tRNATyr]-guanine + queuine | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| QTRT1 | - |
Homo sapiens |
| QTRTD1 | - |
Homo sapiens |
| queuine tRNA-ribosyltransferase 1 | - |
Homo sapiens |
| queuine tRNA-ribosyltransferase domain-containing 1 | - |
Homo sapiens |
| TGT | - |
Homo sapiens |
| tRNA-guanine transglycosylase | - |
Homo sapiens |
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