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Literature summary for 2.4.2.63 extracted from

  • Lee, T.V.; Sethi, M.K.; Leonardi, J.; Rana, N.A.; Buettner, F.F.; Haltiwanger, R.S.; Bakker, H.; Jafar-Nejad, H.
    Negative regulation of Notch signaling by xylose (2013), PLoS Genet., 9, e1003547 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-xylose + [Notch protein with EGF-like domain]-L-serine Drosophila melanogaster
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UDP + [Notch protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-xylose + [Notch protein with EGF-like domain]-L-serine
-
Drosophila melanogaster UDP + [Notch protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine
-
?

Synonyms

Synonyms Comment Organism
CG9996
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Drosophila melanogaster
glucoside xylosyltransferase
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Drosophila melanogaster
Shams
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Drosophila melanogaster

General Information

General Information Comment Organism
malfunction enzyme mutations result in the loss of wing veins and head bristles. Notch surface expression in the pupal wing is increased upon loss of the enzyme Drosophila melanogaster
physiological function xylosylation of epidermal growth factor-like repeats 16-20 by the enzyme negatively regulates the surface expression of the Notch receptor Drosophila melanogaster