Literature summary for 2.4.2.60 extracted from

Chatterjee, A.; Jurgenson, C.; Schroeder, F.; Ealick, S.; Begley, T.
Biosynthesis of thiamin thiazole in eukaryotes Conversion of NAD to an advanced intermediate (2007), J. Am. Chem. Soc., 129, 2914-2922 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
C204A	mutant catalyzes the release of the nicotinamide moiety from NAD to produce ADP-ribose, which is further converted to ADP-ribulose. In the presence of glycine, mutant catalyzes the formation of an advanced intermediate	Saccharomyces cerevisiae
H200N	mutant catalyzes the release of the nicotinamide moiety from NAD to produce ADP-ribose, which is further converted to ADP-ribulose. In the presence of glycine, mutant catalyzes the formation of an advanced intermediate	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P32318	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine	-	Saccharomyces cerevisiae	nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O	-	?

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Release 2023.1 (January 2023)