BRENDA - Enzyme Database show
show all sequences of 2.4.2.6

trans-N-Deoxyribosylase: substrate specificity studies. Purine bases as acceptors

Holguin, J.; Cardinaud, R.; Eur. J. Biochem. 54, 515-520 (1975)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
amino-pyrrolo-pyrimidine
12.1 mM, complete inhibition of the reaction with adenine and deoxycytidine
Lactobacillus helveticus
Hydroxypyrrolopyrimidine
0.33 mM, 66% inhibition of the reaction with adenine and deoxycytidine
Lactobacillus helveticus
imidazole
12.1 mM, 76% inhibition of the reaction with adenine and deoxycytidine
Lactobacillus helveticus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Lactobacillus helveticus
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
deoxycytidine + adenine
-
638043
Lactobacillus helveticus
cytosine + deoxyadenosine
-
-
-
r
thymidine + 1-deaza-8-aza-adenine
21% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 2'-deoxy-1-deaza-8-aza-adenosine
-
-
-
?
thymidine + 1-deaza-adenine
6.2% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 2'-deoxy-1-deaza-adenosine
-
-
-
?
thymidine + 2,6-diaminopurine
53.4% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-2,6-diaminopurine
-
-
-
?
thymidine + 2-amino-6-methyl-mercaptopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-2-amino-6-methylmercaptopurine
-
-
-
r
thymidine + 2-aminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-2-aminopurine
-
-
-
r
thymidine + 2-hydroxy-6-mercaptopurine
-
638043
Lactobacillus helveticus
additional information
2 products
638043
Lactobacillus helveticus
r
thymidine + 2-mercaptoadenine
-
638043
Lactobacillus helveticus
additional information
2 products
638043
Lactobacillus helveticus
r
thymidine + 2-mercaptopurine
-
638043
Lactobacillus helveticus
additional information
2 products
638043
Lactobacillus helveticus
r
thymidine + 3-deaza-8-aza-2-aminopurine
39.7% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-3-deaza-8-aza-aminopurine
-
-
-
?
thymidine + 3-deaza-8-aza-adenine
3.5% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 2'-deoxy-3-deaza-8-aza-adenosine
-
-
-
?
thymidine + 4-amino-5-carboxamide-imidazole
12.3% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + ?
-
-
-
?
thymidine + 4-amino-pyrazolopyrimidine
0.37% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + ?
-
-
-
?
thymidine + 5,6-dimethyl-benzimidazole
37.7% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + ?
-
-
-
?
thymidine + 6-benzylaminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-benzylaminopurine
-
-
-
r
thymidine + 6-chloropurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-chloropurine
-
-
-
r
thymidine + 6-dimethylaminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-dimethylaminopurine
-
-
-
r
thymidine + 6-hydrazinepurine
-
638043
Lactobacillus helveticus
additional information
several products observed
638043
Lactobacillus helveticus
r
thymidine + 6-iodopurine
65.6% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-iodopurine
-
-
-
?
thymidine + 6-mercaptoguanine
52.1% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 6-mercaptoguanosine
-
-
-
?
thymidine + 6-mercatopurine
56.5% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-mercaptopurine
-
-
-
?
thymidine + 6-methoxypurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-methoxypurine
-
-
-
r
thymidine + 6-methylaminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-methylaminopurine
-
-
-
r
thymidine + 6-methylpurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-methylpurine
-
-
-
r
thymidine + 6-n-hexylaminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-n-hexylaminopurine
-
-
-
r
thymidine + 6-n-hexylmercaptopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-n-hexylmercaptopurine
-
-
-
r
thymidine + 6-phenylaminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-phenylaminopurine
-
-
-
r
thymidine + 7-hydroxy-1,2,5-selenadiazolopyridine
29.2% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + ?
-
-
-
?
thymidine + 8-aza-2,6-diaminopurine
59.6% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-8-aza-2,6-diaminopurine
-
-
-
?
thymidine + 8-azaguanine
16.0% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 2'-deoxy-8-azaguanosine
-
-
-
?
thymidine + 8-azaxanthine
-
638043
Lactobacillus helveticus
thymine + 2'-deoxy-8-azaxanthosine
-
-
-
?
thymidine + adenine
-
638043
Lactobacillus helveticus
thymine + 2'-deoxyadenosine
-
-
-
r
thymidine + benzimidazole
33.1% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + ?
-
-
-
?
thymidine + guanine
42.3% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 2'-deoxyguanosine
-
-
-
?
thymidine + hypoxanthine
-
638043
Lactobacillus helveticus
thymine + 2'-deoxyinosine
-
-
-
r
thymidine + purine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-purine
-
-
-
r
thymidine + theophylline
-
638043
Lactobacillus helveticus
thymine + 2'-deoxytheophylline riboside
-
-
-
?
thymidine + xanthine
-
638043
Lactobacillus helveticus
thymine + xanthosine
-
-
-
r
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
amino-pyrrolo-pyrimidine
12.1 mM, complete inhibition of the reaction with adenine and deoxycytidine
Lactobacillus helveticus
Hydroxypyrrolopyrimidine
0.33 mM, 66% inhibition of the reaction with adenine and deoxycytidine
Lactobacillus helveticus
imidazole
12.1 mM, 76% inhibition of the reaction with adenine and deoxycytidine
Lactobacillus helveticus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
deoxycytidine + adenine
-
638043
Lactobacillus helveticus
cytosine + deoxyadenosine
-
-
-
r
thymidine + 1-deaza-8-aza-adenine
21% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 2'-deoxy-1-deaza-8-aza-adenosine
-
-
-
?
thymidine + 1-deaza-adenine
6.2% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 2'-deoxy-1-deaza-adenosine
-
-
-
?
thymidine + 2,6-diaminopurine
53.4% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-2,6-diaminopurine
-
-
-
?
thymidine + 2-amino-6-methyl-mercaptopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-2-amino-6-methylmercaptopurine
-
-
-
r
thymidine + 2-aminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-2-aminopurine
-
-
-
r
thymidine + 2-hydroxy-6-mercaptopurine
-
638043
Lactobacillus helveticus
additional information
2 products
638043
Lactobacillus helveticus
r
thymidine + 2-mercaptoadenine
-
638043
Lactobacillus helveticus
additional information
2 products
638043
Lactobacillus helveticus
r
thymidine + 2-mercaptopurine
-
638043
Lactobacillus helveticus
additional information
2 products
638043
Lactobacillus helveticus
r
thymidine + 3-deaza-8-aza-2-aminopurine
39.7% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-3-deaza-8-aza-aminopurine
-
-
-
?
thymidine + 3-deaza-8-aza-adenine
3.5% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 2'-deoxy-3-deaza-8-aza-adenosine
-
-
-
?
thymidine + 4-amino-5-carboxamide-imidazole
12.3% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + ?
-
-
-
?
thymidine + 4-amino-pyrazolopyrimidine
0.37% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + ?
-
-
-
?
thymidine + 5,6-dimethyl-benzimidazole
37.7% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + ?
-
-
-
?
thymidine + 6-benzylaminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-benzylaminopurine
-
-
-
r
thymidine + 6-chloropurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-chloropurine
-
-
-
r
thymidine + 6-dimethylaminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-dimethylaminopurine
-
-
-
r
thymidine + 6-hydrazinepurine
-
638043
Lactobacillus helveticus
additional information
several products observed
638043
Lactobacillus helveticus
r
thymidine + 6-iodopurine
65.6% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-iodopurine
-
-
-
?
thymidine + 6-mercaptoguanine
52.1% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 6-mercaptoguanosine
-
-
-
?
thymidine + 6-mercatopurine
56.5% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-mercaptopurine
-
-
-
?
thymidine + 6-methoxypurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-methoxypurine
-
-
-
r
thymidine + 6-methylaminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-methylaminopurine
-
-
-
r
thymidine + 6-methylpurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-methylpurine
-
-
-
r
thymidine + 6-n-hexylaminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-n-hexylaminopurine
-
-
-
r
thymidine + 6-n-hexylmercaptopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-n-hexylmercaptopurine
-
-
-
r
thymidine + 6-phenylaminopurine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-phenylaminopurine
-
-
-
r
thymidine + 7-hydroxy-1,2,5-selenadiazolopyridine
29.2% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + ?
-
-
-
?
thymidine + 8-aza-2,6-diaminopurine
59.6% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-8-aza-2,6-diaminopurine
-
-
-
?
thymidine + 8-azaguanine
16.0% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 2'-deoxy-8-azaguanosine
-
-
-
?
thymidine + 8-azaxanthine
-
638043
Lactobacillus helveticus
thymine + 2'-deoxy-8-azaxanthosine
-
-
-
?
thymidine + adenine
-
638043
Lactobacillus helveticus
thymine + 2'-deoxyadenosine
-
-
-
r
thymidine + benzimidazole
33.1% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + ?
-
-
-
?
thymidine + guanine
42.3% of substrate converted into deoxynucleoside after 2 h
638043
Lactobacillus helveticus
thymine + 2'-deoxyguanosine
-
-
-
?
thymidine + hypoxanthine
-
638043
Lactobacillus helveticus
thymine + 2'-deoxyinosine
-
-
-
r
thymidine + purine
-
638043
Lactobacillus helveticus
thymine + 9-(2-deoxy-beta-D-ribofuranosyl)-purine
-
-
-
r
thymidine + theophylline
-
638043
Lactobacillus helveticus
thymine + 2'-deoxytheophylline riboside
-
-
-
?
thymidine + xanthine
-
638043
Lactobacillus helveticus
thymine + xanthosine
-
-
-
r
Other publictions for EC 2.4.2.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736575
Britos
-
Biotransformation of halogenat ...
Lactobacillus animalis
J. Fluor. Chem.
186
91-96
2016
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1
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1
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736936
Vichier-Guerre
Expedient and generic synthesi ...
Lactobacillus leichmannii
Org. Biomol. Chem.
14
3638-3653
2016
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24
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24
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736846
Fresco-Taboada
Nucleoside 2'-deoxyribosyltran ...
Bacillus psychrosaccharolyticus, Bacillus psychrosaccharolyticus CECT 4074
Molecules
19
11231-11249
2014
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1
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1
1
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1
2
2
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6
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1
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10
1
1
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2
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1
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10
1
1
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1
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1
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1
1
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737137
Ye
Ethenoguanines undergo glycosy ...
Lactobacillus fermentum
PLoS ONE
9
e115082
2014
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1
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6
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2
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722820
Kaminski
Phosphodeoxyribosyltransferase ...
Lactobacillus leichmannii
J. Biol. Chem.
288
6534-6541
2013
-
-
1
-
-
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2
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2
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6
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2
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1
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6
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2
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2
2
735536
Fresco-Taboada
New insights on nucleoside 2'- ...
Lactobacillus leichmannii, Lactococcus lactis
Appl. Microbiol. Biotechnol.
97
3773-3785
2013
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2
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6
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6
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736587
Fernandez-Lucas
Magnetic chitosan beads for co ...
Lactobacillus reuteri
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