Literature summary for 2.4.2.54 extracted from

Zhang, M.; Zhang, P.; Xu, G.; Zhou, W.; Gao, Y.; Gong, R.; Cai, Y.; Cong, H.; Deng, Z.; Price, N.; Mao, X.; Chen, W.
Comparative investigation into formycin a and pyrazofurin a biosynthesis reveals branch pathways for the construction of C-nucleoside scaffolds (2020), Appl. Environ. Microbiol., 86, e01971-19 .

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	20 mM used in assay conditions	Streptomyces candidus
Mn2+	20 mM used in assay conditions	Streptomyces kaniharaensis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate	Streptomyces candidus	-	4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate	-	?
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate	Streptomyces kaniharaensis	-	4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate	-	?
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate	Streptomyces candidus NRRL 3601	-	4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate	-	?
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate	Streptomyces kaniharaensis ATCC 21070	-	4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Streptomyces candidus	-	-	-
Streptomyces candidus NRRL 3601	-	-	-
Streptomyces kaniharaensis	-	-	-
Streptomyces kaniharaensis ATCC 21070	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Streptomyces candidus
-	Streptomyces kaniharaensis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-phospho-alpha-D-ribose 1-diphosphate + 4-amino-3,5-dicarboxypyrazole	-	Streptomyces candidus	4-amino-3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate	-	?
5-phospho-alpha-D-ribose 1-diphosphate + 4-amino-3,5-dicarboxypyrazole	-	Streptomyces candidus NRRL 3601	4-amino-3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate	-	?
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxy-3,5-dicarboxypyrazole	-	Streptomyces kaniharaensis	3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-4-hydroxy-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate	-	?
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxy-3,5-dicarboxypyrazole	-	Streptomyces kaniharaensis ATCC 21070	3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-4-hydroxy-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate	-	?
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate	-	Streptomyces candidus	4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate	-	?
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate	-	Streptomyces kaniharaensis	4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate	-	?
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate	-	Streptomyces candidus NRRL 3601	4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate	-	?
5-phospho-alpha-D-ribose 1-diphosphate + 4-hydroxybenzoate	-	Streptomyces kaniharaensis ATCC 21070	4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
beta-RFA-P synthase	-	Streptomyces candidus
beta-RFA-P synthase	-	Streptomyces kaniharaensis
beta-ribofuranosyl-aminobenzene 5'-phosphate synthase	-	Streptomyces candidus
beta-ribofuranosyl-aminobenzene 5'-phosphate synthase	-	Streptomyces kaniharaensis
ForT	-	Streptomyces kaniharaensis
PrfT	-	Streptomyces candidus

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Release 2023.1 (January 2023)