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Literature summary for 2.4.2.53 extracted from
- The pmrF polymyxin-resistance operon of Yersinia pseudotuberculosis is upregulated by the PhoP-PhoQ two-component system but not by PmrA-PmrB, and is not required for virulence (2004), Microbiology, 150, 3947-3957.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Yersinia pseudotuberculosis | Q93PD9 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PmrF | - |
Yersinia pseudotuberculosis |
| polymyxin resistance protein F | - |
Yersinia pseudotuberculosis |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Yersinia pseudotuberculosis | pmrF expression is independent of polymyxin resistance proteins PmrA-PmrB in Yersinia pseudotuberculosis, with the response regulator PhoP interacting directly with the pmrF operon promoter region | additional information |
| Yersinia pseudotuberculosis | low Mg2+/Ca2+ concentration of 1 mM and a pH decrease from 8 to 6 both induce polymyxin resistance. Transcription of the pmrF operon in Yersinia pseudotuberculosis increases accordingly, by a factor of 7 and 2.5 for the Mg2+/Ca2+ ion starvation and acidic pH conditions, respectively | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | pmrF inactivation in Yersinia pseudotuberculosis has no effect on bacterial virulence in the mouse | Yersinia pseudotuberculosis |
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