Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.45 extracted from

  • Safi, H.; Lingaraju, S.; Amin, A.; Kim, S.; Jones, M.; Holmes, M.; McNeil, M.; Peterson, S.N.; Chatterjee, D.; Fleischmann, R.; Alland, D.
    Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-alpha-D-arabinose biosynthetic and utilization pathway genes (2013), Nat. Genet., 45, 1190-1197.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.45

Protein Variants

Protein Variants Comment Organism
A35E the mutant is associated with high-level ethambutol resistance and increases decaprenylphosphoryl-beta-D-arabinose levels Mycobacterium tuberculosis
G165C the mutant is associated with high-level ethambutol resistance and increases decaprenylphosphoryl-beta-D-arabinose levels Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
ethambutol
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate Mycobacterium tuberculosis
-
 trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WFR5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mycobacterium tuberculosis trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
5-phospho-alpha-FS18 D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase
-
 Mycobacterium tuberculosis
DPPR synthase
-
 Mycobacterium tuberculosis
Rv3806
-
 Mycobacterium tuberculosis
ubiA
-
 Mycobacterium tuberculosis