Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-N'-(2,3-dimethoxybenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(2,4-dichlorobenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(2-cyanobenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(2-nitrobenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(3,5-dichloro-2-hydroxybenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(3-cyanobenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(3-hydroxy-5-methoxybenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(4-chlorobenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(4-cyanobenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(4-nitrobenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(5-bromo-2-methoxybenzlidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(E)-N'-(anthracen-9-ylmethylen)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(Z)-N'-(1-(4-nitrophenyl)ethylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(Z)-N'-(3-chloro-4-hydroxybenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
(Z)-N'-(4-hydroxy-3,5-dimethoxybenzylidene)isoquinoline-3-carbohydrazide | - |
Escherichia coli | |
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl] uracil hydrochloride | TPI | Escherichia coli | |
7-deazaxanthine | 7DX | Escherichia coli | |
additional information | in vitro study of thymidine phosphorylase inhibition, overview. Sixteen analogs of N-benzyliden-isoquinoline-3-carbohydrazide are synthesized and evaluated their inhibitory activity against thymidine phosphorylase enzyme, molecular docking study using structure with PDB ID 4EAD as template. No inhibition by (Z)-N'-(3-methoxy-4-(phenoxymethyl)benzylidene)isoquinoline-3-carbohydrazide | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | Escherichia coli | - |
thymidine + phosphate | - |
r | |
uracil + 2-deoxy-alpha-D-ribose 1-phosphate | Escherichia coli | - |
2'-deoxyuridine + phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0C037 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Escherichia coli | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
Escherichia coli | thymidine + phosphate | - |
r | |
uracil + 2-deoxy-alpha-D-ribose 1-phosphate | - |
Escherichia coli | 2'-deoxyuridine + phosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ppnP | - |
Escherichia coli |
pyrimidine/purine nucleoside phosphorylase | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0044 | - |
pH 7.4, 25°C | Escherichia coli | (Z)-N'-(4-hydroxy-3,5-dimethoxybenzylidene)isoquinoline-3-carbohydrazide | |
0.0081 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(3,5-dichloro-2-hydroxybenzylidene)isoquinoline-3-carbohydrazide | |
0.0081 | - |
pH 7.4, 25°C | Escherichia coli | (Z)-N'-(3-chloro-4-hydroxybenzylidene)isoquinoline-3-carbohydrazide | |
0.0086 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(2,4-dichlorobenzylidene)isoquinoline-3-carbohydrazide | |
0.0113 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(2-nitrobenzylidene)isoquinoline-3-carbohydrazide | |
0.0161 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(3-hydroxy-5-methoxybenzylidene)isoquinoline-3-carbohydrazide | |
0.0184 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(2-cyanobenzylidene)isoquinoline-3-carbohydrazide | |
0.0184 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(4-chlorobenzylidene)isoquinoline-3-carbohydrazide | |
0.0214 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(4-nitrobenzylidene)isoquinoline-3-carbohydrazide | |
0.0222 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(4-cyanobenzylidene)isoquinoline-3-carbohydrazide | |
0.0276 | - |
pH 7.4, 25°C | Escherichia coli | (Z)-N'-(1-(4-nitrophenyl)ethylidene)isoquinoline-3-carbohydrazide | |
0.0361 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(3-cyanobenzylidene)isoquinoline-3-carbohydrazide | |
0.03868 | - |
pH 7.4, 25°C | Escherichia coli | 7-deazaxanthine | |
0.0394 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(2,3-dimethoxybenzylidene)isoquinoline-3-carbohydrazide | |
0.0447 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(5-bromo-2-methoxybenzlidene)isoquinoline-3-carbohydrazide | |
0.0693 | - |
pH 7.4, 25°C | Escherichia coli | (E)-N'-(anthracen-9-ylmethylen)isoquinoline-3-carbohydrazide |
General Information | Comment | Organism |
---|---|---|
metabolism | thymidine phosphorylase (TP) is the key enzyme of the pyrimidine salvage pathway, which speedup the conversion of thymidine and 2'-deoxyuridine to their respective bases and 2-deoxy-D-ribose 1-phosphate | Escherichia coli |