Literature summary for 2.4.2.4 extracted from

Chen, L.C.; Liu, H.P.; Li, H.P.; Hsueh, C.; Yu, J.S.; Liang, C.L.; Chang, Y.S.
Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells (2009), Oncogene, 28, 1904-1915.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
nasopharyngeal carcinoma cell	the cytoplasmic level of heterogeneous nuclear ribonucleoprotein K is significantly correlated with the elevated expression of thymidine phosphorylase, and high levels of both proteins are predictive of a poor prognosis in nasopharyngeal carcinoma	Homo sapiens	-
NPC-TW01 cell	the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cells, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, overview	Homo sapiens	-
NPC-TW02 cell	the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cells, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, overview	Homo sapiens	-
NPC-TW04 cell	the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cells, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, overview	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
gliostatin	-	Homo sapiens
PD-ECGF	-	Homo sapiens
platelet-derived endothelial cell growth factor	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cell lines TW-01, TW-02, and TW-04, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, mechanism and kinetics, overview	up

General Information

General Information	Comment	Organism
additional information	the cytoplasmic level of heterogeneous nuclear ribonucleoprotein K is significantly correlated with the elevated expression of thymidine phosphorylase, and high levels of both proteins are predictive of a poor prognosis in nasopharyngeal carcinoma	Homo sapiens
physiological function	heterogeneous nuclear ribonucleoprotein K and thymidine phosphorylase prevent hypoxia-induced apoptosis in nasopharyngeal carcinoma cells, overview	Homo sapiens

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Release 2023.1 (January 2023)