Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cyclophosphamide | induces thymidine phosphorylase expression | Homo sapiens | |
docetaxel | induces thymidine phosphorylase expression | Homo sapiens | |
interferon alpha | causes a rapid and transient increase of thymidine phosphorylase expression | Homo sapiens | |
interferon beta | causes a rapid and transient increase of thymidine phosphorylase expression | Homo sapiens | |
interferon gamma | causes a rapid and transient increase of thymidine phosphorylase expression | Homo sapiens | |
interleukin-1beta | the expression of tyhmidine phosphorylase mRNA is significantly increased by stimulation with interleukin-1beta | Homo sapiens | |
mitomycin C | induces thymidine phosphorylase expression | Homo sapiens | |
additional information | the enzymatic activity of thymidine phosphorylase is required for the activation of 5-fluorouracil prodrugs, the enzyme induces the expression of several matrix metalloproteinases, increases the levels of hypoxia-inducible factor 1alpha during in vitro hypoxia | Homo sapiens | |
paclitaxel | induces thymidine phosphorylase expression | Homo sapiens | |
Tumor necrosis factor alpha | causes a rapid and transient increase of thymidine phosphorylase expression | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | thymidine phosphorylase expression correlates well with tumor grade, metastasis and shorter patient survival in colorectal, pancreatic, renal, ovarian, cervical, bladder and non-small cell lung cancer, loss of function mutants of thymidine phosphorylase case the disease mitochondrial neurogastrointestinal encephalomyopathy | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
L148R | mutant devoid of enzymatic activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-O-tritylinosine | - |
Homo sapiens | |
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl]uracil hydrochloride | - |
Homo sapiens | |
6-amino-5-bromouracil | - |
Homo sapiens | |
6-amino-5-chlorouracil | - |
Homo sapiens | |
6-aminothymine | - |
Homo sapiens | |
aurothioglucose | the expression of tyhmidine phosphorylase mRNA is significantly decreased by stimulation with aurothioglucose | Homo sapiens | |
dexamethasone | the expression of tyhmidine phosphorylase mRNA is significantly decreased by stimulation with dexamethasone | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-431 cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
gastrointestinal tract | high expression | Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
KK-47 cell | - |
Homo sapiens | - |
MKN-74 cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
RT-112 cell | - |
Homo sapiens | - |
THP-1 cell | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-deoxy-5-fluorouridine + phosphate | - |
Homo sapiens | 5-fluorouracil + 5-deoxyribose-1-phosphate | - |
? | |
5-fluoro-2'-deoxyuridine + phosphate | - |
Homo sapiens | 5-fluorouracil + 2-deoxyribose-1-phosphate | - |
r | |
thymidine + phosphate | - |
Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | x-ray crystallography | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
gliostatin | - |
Homo sapiens |
PD-ECGF | - |
Homo sapiens |
platelet-derived endothelial cell growth factor | - |
Homo sapiens |