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Literature summary for 2.4.2.38 extracted from

  • Faust, I.; Roch, C.; Kuhn, J.; Prante, C.; Knabbe, C.; Hendig, D.
    Human xylosyltransferase-I - a new marker for myofibroblast differentiation in skin fibrosis (2013), Biochem. Biophys. Res. Commun., 436, 449-454.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is a biomarker for myofibroblast differentiation and fibrotic development Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dermal fibroblast
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
XT-I
-
Homo sapiens
xylosyltransferase-I
-
Homo sapiens
XYLT1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens isoform XYLT1 expression is inhibited by transforming growth factor-beta receptor I inhibitor SB431542 down
Homo sapiens treatment of normal human dermal fibroblasts with transforming growth factor-beta1 is followed by increased relative isoform XYLT1 mRNA expression. Moreover, enzyme activity increases time-dependently in response to progressive myofibroblast transformation up

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the initial step of glycosaminoglycan biosynthesis Homo sapiens