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Literature summary for 2.4.2.31 extracted from

  • Goncalves, C.; Decre, D.; Barbut, F.; Burghoffer, B.; Petit, J.
    Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile (2004), J. Clin. Microbiol., 42, 1933-1939.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.31

Organism

Organism UniProt Comment Textmining
Clostridioides difficile
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
actin + NAD+
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 Clostridioides difficile ?
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 ?

Synonyms

Synonyms Comment Organism
binary toxin
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 Clostridioides difficile
CDT
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 Clostridioides difficile

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Clostridioides difficile

General Information

General Information Comment Organism
physiological function enzyme is an actin-specific ADP-ribosyltransferase, called binary toxin CDT, present in about 6% of strains isolated from patients with suspected Peptoclostridium difficile-associated diarrhea or colitis. All binary toxin-positive strains tested also produce toxins TcdB and/or TcdA. However, they have significant changes in the tcdA and tcdB genes and belong to variant toxinotypes III, IV, V, VII, IX, and XIII Clostridioides difficile