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Literature summary for 2.4.2.30 extracted from

  • Verheugd, P.; Forst, A.H.; Milke, L.; Herzog, N.; Feijs, K.L.; Kremmer, E.; Kleine, H.; Luescher, B.
    Regulation of NF-kappaB signalling by the mono-ADP-ribosyltransferase ARTD10 (2013), Nat. Commun., 4, 1683.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-NEMO protein Homo sapiens the enzyme prevents poly-ubiquitination of NEMO protein nicotinamide + (ADP-D-ribosyl)n+1-NEMO protein + H+
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q53GL7
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-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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U2OS cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-NEMO protein the enzyme prevents poly-ubiquitination of NEMO protein Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-NEMO protein + H+
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?

Synonyms

Synonyms Comment Organism
ARTD10 formerly PARP10 Homo sapiens
mono-ADP-ribosyltransferase
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Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme inhibits the activation of NF-kappaB and downstream target genes in response to interleukin-1beta and tumour necrosis factor-alpha, dependent on catalytic activity and poly-ubiquitin binding Homo sapiens