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Literature summary for 2.4.2.30 extracted from

  • Meyer-Ficca, M.L.; Ihara, M.; Bader, J.J.; Leu, N.A.; Beneke, S.; Meyer, R.G.
    Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice (2015), Biol. Reprod., 92, 80.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nuclear envelope
-
Homo sapiens 5635
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme has the ability to ADP-ribosylate itself ?
-
?
NAD+ + (ADP-D-ribosyl)n-acceptor Homo sapiens
-
nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme has the ability to ADP-ribosylate itself Homo sapiens ?
-
?
NAD+ + (ADP-D-ribosyl)n-acceptor
-
Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
?

Synonyms

Synonyms Comment Organism
ADP-ribosyltransferase
-
Homo sapiens
ARTD11
-
Homo sapiens
mono(ADP-ribosyl) transferase
-
Homo sapiens
PARP11
-
Homo sapiens
poly(ADP-ribose) polymerase-11
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme deletion results in teratozoospermia and male infertility in mice due to the formation of abnormally shaped fertilization-incompetent sperm, despite normal testis weights and sperm counts Homo sapiens
physiological function the enzyme displays functional relevance for nuclear envelope stability and nuclear reorganization during spermiogenesis and is important for proper sperm head shaping Homo sapiens