Cloned (Comment) | Organism |
---|---|
expression of ExoT and the isolated GAP and ADPRT enzyme domains, respectively, in A-549 cells | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Pseudomonas aeruginosa | Pseudomonas aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T-dependent manner, the ADP-ribosyl transferase domain inhibits late steps of cytokinesis by blocking syntaxin-2 localization to the midbody, an event essential for completion of cytokinesis, e.g. in Madin-Darby canine kidney cells, mechanism, overview | ? | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | Pseudomonas aeruginosa | - |
nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Pseudomonas aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T-dependent manner, the ADP-ribosyl transferase domain inhibits late steps of cytokinesis by blocking syntaxin-2 localization to the midbody, an event essential for completion of cytokinesis, e.g. in Madin-Darby canine kidney cells, mechanism, overview | Pseudomonas aeruginosa | ? | - |
? | |
additional information | ExoT is a bifunctional type III secretion system effector protein that contains an N-terminal GTPase-activating protein domain and a C-terminal ADP-ribosyl transferase domain | Pseudomonas aeruginosa | ? | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | - |
Pseudomonas aeruginosa | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the bifunctional ExoT contains an N-terminal GTPase-activating protein domain, GAP domain, and a C-terminal ADP-ribosyl transferase domain, ADPRT domain | Pseudomonas aeruginosa |
Synonyms | Comment | Organism |
---|---|---|
ExoT | - |
Pseudomonas aeruginosa |
type III-secreted toxin | - |
Pseudomonas aeruginosa |