BRENDA - Enzyme Database
show all sequences of 2.4.2.30

In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)

Otto, H.; Reche, P.A.; Bazan, F.; Dittmar, K.; Haag, F.; Koch-Nolte, F.; BMC Genomics 6, 139 (2005)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene PARP, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Mus musculus
gene PARP11, chromosomal location 12p13.3, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP14, chromosomal location 3q21.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP16, chromosomal location 15q22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP1, chromosomal location 1q41-q42, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP2, chromosomal location 14q11.2-q12, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP3, chromosomal location 3p21.1-22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP4, chromosomal location 13q11, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene PARP6, chromosomal location 15q22.23, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview; gene TNKS1, chromosomal location 8p23.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
NAD+ + (ADP-D-ribosyl)n-acceptor
Mus musculus
-
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
?
NAD+ + (ADP-D-ribosyl)n-acceptor
Homo sapiens
-
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
O95271
TNKS1
-
Homo sapiens
P09874
PARP-1
-
Homo sapiens
Q2NL67
PARP-6
-
Homo sapiens
Q460N5
PARP-14
-
Homo sapiens
Q8N5Y8
PARP-16
-
Homo sapiens
Q9NR21
PARP-11
-
Homo sapiens
Q9UGN5
PARP-2
-
Homo sapiens
Q9UKK3
PARP-4
-
Homo sapiens
Q9Y6F1
PARP-3
-
Mus musculus
-
-
-
Reaction
Reaction
Commentary
Organism
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains; the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains
Homo sapiens
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
NAD+ + (ADP-D-ribosyl)n-acceptor
-
672801
Mus musculus
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-acceptor
-
672801
Homo sapiens
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
gene PARP, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Mus musculus
gene PARP1, chromosomal location 1q41-q42, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Homo sapiens
gene PARP11, chromosomal location 12p13.3, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Homo sapiens
gene PARP14, chromosomal location 3q21.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Homo sapiens
gene PARP16, chromosomal location 15q22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Homo sapiens
gene PARP2, chromosomal location 14q11.2-q12, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Homo sapiens
gene PARP3, chromosomal location 3p21.1-22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Homo sapiens
gene PARP4, chromosomal location 13q11, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Homo sapiens
gene PARP6, chromosomal location 15q22.23, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Homo sapiens
gene TNKS1, chromosomal location 8p23.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
NAD+ + (ADP-D-ribosyl)n-acceptor
Mus musculus
-
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
?
NAD+ + (ADP-D-ribosyl)n-acceptor
Homo sapiens
-
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
NAD+ + (ADP-D-ribosyl)n-acceptor
-
672801
Mus musculus
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-acceptor
-
672801
Homo sapiens
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
-
?
Other publictions for EC 2.4.2.30
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736500
Lyons
Scabin, a Novel DNA-acting ADP ...
Streptomyces scabiei, Streptomyces scabiei 87.22
J. Biol. Chem.
291
11198-11215
2016
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1
1
1
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4
1
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2
2
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4
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1
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4
1
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2
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5
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1
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1
1
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4
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2
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1
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4
1
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2
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736518
Pinto
Identification of inhibitors o ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAK
J. Biomol. Screen.
21
590-595
2016
1
-
1
-
-
-
7
1
-
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8
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1
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2
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7
1
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7
1
1
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736818
Liu
A mutated cholera toxin withou ...
Mus musculus
Mol. Immunol.
75
21-27
2016
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2
2
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735741
Meyer-Ficca
Spermatid head elongation with ...
Homo sapiens
Biol. Reprod.
92
80
2015
-
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1
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1
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2
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2
2
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736238
Picchianti
NAD-dependent ADP-ribosylation ...
Homo sapiens
Innate Immun.
21
314-321
2015
-
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-
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2
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1
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736475
Krska
C3larvin toxin, an ADP-ribosyl ...
Paenibacillus larvae subsp. larvae, Paenibacillus larvae subsp. larvae BRL-230010
J. Biol. Chem.
290
1639-1653
2015
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1
1
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2
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1
2
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5
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1
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1
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4
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2
1
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1
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736583
Menzel
Nucleotide-induced membrane-pr ...
Mus musculus
J. Immunol.
195
2057-2066
2015
-
-
1
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-
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1
2
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2
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1
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1
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737081
Valeri
The Neisseria meningitidis ADP ...
Neisseria meningitidis
PLoS ONE
10
e0127614
2015
-
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1
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1
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1
1
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1
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1
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1
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736446
Nicolae
The ADP-ribosyltransferase PAR ...
Homo sapiens
J. Biol. Chem.
289
13627-13637
2014
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2
2
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735670
Simon
Host cell cytotoxicity and cyt ...
Bacillus cereus, Bacillus cereus G9241
Biochemistry
52
2309-2318
2013
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1
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1
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3
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1
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1
1
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736061
Venkannagari
Activity-based assay for human ...
Homo sapiens
Eur. J. Pharm. Sci.
49
148-156
2013
-
-
1
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1
-
15
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1
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3
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1
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1
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6
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2
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6
30
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2
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736615
Lindgren
Chemical probes to study ADP-r ...
Homo sapiens
J. Med. Chem.
56
9556-9568
2013
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1
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15
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14
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14
15
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736869
Verheugd
Regulation of NF-kappaB signal ...
Homo sapiens
Nat. Commun.
4
1683
2013
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1
1
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736899
MacPherson
2,3,7,8-Tetrachlorodibenzo-p-d ...
Homo sapiens
Nucleic Acids Res.
41
1604-1621
2013
-
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3
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1
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1
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1
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722786
Shniffer
Characterization of an actin-t ...
Aeromonas hydrophila
J. Biol. Chem.
287
37030-37041
2012
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1
6
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5
14
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14
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4
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6
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4
5
4
14
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1
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14
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723512
Boamah
-
Poly(ADP-ribose) polymerase 1 ...
Drosophila melanogaster
PLoS Genet.
8
0000
2012
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1
1
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722703
Koehler
Structural and biochemical cha ...
Neisseria meningitidis
J. Biol. Chem.
286
14842-14851
2011
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1
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3
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723446
Arena
Characterization and role of p ...
Cistus incanus
Plant Physiol. Biochem.
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435-440
2011
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8
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1
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1
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1
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1
1
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694800
Arnoldo
Identification of small molecu ...
Pseudomonas aeruginosa
PLoS Genet.
4
e1000005
2008
1
1
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8
2
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1
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2
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7
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3
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1
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4
8
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2
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3
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1
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1
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695219
Deng
Modulation of host cell endocy ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa PA103
Traffic
9
1948-1957
2008
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-
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3
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1
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8
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6
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10
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8
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10
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671255
Pagano
Poly(ADP-ribose) polymerase-1 ...
Mus musculus, Mus musculus Sv129
Am. J. Physiol. Lung Cell Mol. Physiol.
293
L619-L629
2007
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1
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5
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2
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671265
Chen
Proteomic identification of pr ...
Homo sapiens
Am. J. Physiol. Renal Physiol.
292
F981-F992
2007
1
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1
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1
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1
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2
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2
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672809
Aguilar-Quesada
Interaction between ATM and PA ...
Mus musculus
BMC Mol. Biol.
8
29
2007
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1
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3
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2
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1
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1
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1
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672996
Maresso
Pseudomonas aeruginosa ExoS AD ...
Pseudomonas aeruginosa
Cell. Microbiol.
9
97-105
2007
1
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1
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1
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5
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1
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7
1
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5
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7
1
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1
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675533
Infante
Poly (ADP-ribose) polymerase-1 ...
Homo sapiens
J. Neurol. Sci.
256
68-70
2007
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-
1
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1
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2
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1
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672048
Vogelsgesang
Exchange of glutamine-217 to g ...
Hathewaya limosa
Biochemistry
45
1017-1025
2006
-
-
1
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5
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1
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1
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7
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1
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1
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7
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1
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1
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1
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5
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1
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1
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1
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7
-
1
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1
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-
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-
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-
-
-
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672150
DiNovo
ADP-ribosylation of cyclophili ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa 388
Biochemistry
45
4664-4673
2006
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-
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1
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2
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5
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6
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6
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673573
Yasmin
Delineation of exoenzyme S res ...
Pseudomonas aeruginosa
FEBS J.
273
638-646
2006
1
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1
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14
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3
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2
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1
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3
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1
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14
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3
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675627
Banasik
Differential effects of hetero ...
Bos taurus
J. Physiol. Pharmacol.
57 Suppl 4
15-22
2006
1
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3
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3
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1
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1
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2
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1
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1
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-
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-
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-
-
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676203
Baumann
Poly(ADP-RIBOSE) polymerase-1 ...
Mus musculus
Nucleic Acids Res.
34
1036-1049
2006
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-
1
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1
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4
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1
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6
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1
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6
-
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676823
Shafikhani
Pseudomonas aeruginosa type II ...
Pseudomonas aeruginosa
Proc. Natl. Acad. Sci. USA
103
15605-15610
2006
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1
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2
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2
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1
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1
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3
1
-
-
-
-
-
-
-
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-
-
-
-
-
-
658344
Bannas
Activity and specificity of to ...
Mus musculus
Blood
105
3663-3670
2005
-
-
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1
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2
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3
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3
-
-
2
-
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-
-
-
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-
-
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-
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659466
Lonskaya
Regulation of poly(ADP-ribose) ...
Homo sapiens
J. Biol. Chem.
280
17076-17083
2005
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-
-
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1
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1
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2
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-
-
-
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-
-
-
-
-
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-
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-
-
671826
Zhao
ADP-ribosylation of integrin a ...
Mus musculus
Biochem. J.
385
309-317
2005
-
-
-
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1
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-
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1
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1
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1
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3
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2
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1
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1
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1
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1
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1
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3
-
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2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
672801
Otto
In silico characterization of ...
Homo sapiens, Mus musculus
BMC Genomics
6
139
2005
-
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2
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-
-
-
-
-
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10
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10
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2
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10
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10
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-
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10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672969
Helleday
Poly(ADP-ribose) polymerase (P ...
Mus musculus
Cell Cycle
4
1176-1178
2005
1
1
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1
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-
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2
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2
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1
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3
1
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1
1
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1
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3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673854
Kim
Poly(ADP-ribosyl)ation by PARP ...
Drosophila melanogaster, Mus musculus
Genes Dev.
19
1951-1967
2005
-
-
2
-
2
-
-
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2
-
-
4
-
2
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6
1
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2
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2
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2
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4
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6
1
-
-
-
-
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-
-
-
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-
-
-
-
675022
Carrillo
Establishment of an immortaliz ...
Mus musculus 129/Sv x C57BL/6, Mus musculus
J. Cell. Biochem.
94
1163-1174
2005
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2
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1
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2
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5
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3
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2
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2
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1
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2
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3
-
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2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
675025
Siles
PARP-1-dependent 3-nitrotyrosi ...
Mus musculus
J. Cell. Biochem.
96
709-715
2005
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-
-
-
1
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-
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1
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2
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1
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1
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1
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1
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1
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-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
659054
Tiemann
ModA and ModB, two ADP-ribosyl ...
Escherichia virus T4, Escherichia virus T4 ModA, Escherichia virus T4 ModB
J. Bacteriol.
186
7262-7272
2004
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1
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19
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-
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1
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3
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1
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2
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1
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19
-
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1
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1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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659706
Mendoza-Alvarez
The 40 kDa carboxy-terminal do ...
Gallus gallus
J. Mol. Biol.
336
105-114
2004
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-
1
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-
-
-
-
-
-
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1
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1
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1
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661784
Sundin
ADP-ribosylation by exoenzyme ...
Pseudomonas aeruginosa
FEMS Microbiol. Lett.
234
87-91
2004
-
-
-
-
-
-
-
-
2
-
-
1
-
4
-
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-
-
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1
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-
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2
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661878
Garrity-Ryan
The ADP ribosyltransferase dom ...
Pseudomonas aeruginosa
Infect. Immun.
72
546-558
2004
-
-
-
-
1
-
-
-
-
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-
1
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5
-
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1
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1
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1
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662234
Krall
Intracellular membrane localiz ...
Pseudomonas aeruginosa
J. Biol. Chem.
279
2747-2753
2004
-
-
-
-
-
-
-
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1
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1
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663377
Barbieri
Pseudomonas aeruginosa ExoS an ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa ExoS, Pseudomonas aeruginosa ExoT
Rev. Physiol. Biochem. Pharmacol.
152
79-92
2004
-
-
-
-
-
-
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1
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4
-
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6
-
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1
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-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657940
Ritter
Substrate binding and catalysi ...
Rattus norvegicus
Biochemistry
42
10155-10162
2003
-
-
-
1
4
-
-
1
-
-
-
-
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2
-
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-
-
-
-
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1
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4
-
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-
-
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-
1
4
-
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1
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-
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-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
658013
Wilde
Rho-specific Bacillus cereus A ...
Bacillus cereus, Bacillus cereus 2339
Biochemistry
42
9694-9702
2003
-
-
1
-
11
-
-
3
-
-
-
-
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6
-
-
-
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-
1
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6
-
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-
-
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1
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1
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11
-
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3
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1
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
-
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658546
Garcia-Salcedo
A chromosomal SIR2 homologue w ...
Trypanosoma brucei
EMBO J.
22
5851-5862
2003
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