Literature summary for 2.4.2.30 extracted from

Pederson, K.J.; Pal, S.; Vallis, A.J.; Frank, D.W.; Barbieri, J.T.
Intracellular localization and processing of Pseudomonas aeruginosa ExoS in eukaryotic cells (2000), Mol. Microbiol., 37, 287-299.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
perinuclear space	localizes in eukaryotic cells to the perinuclear region	Pseudomonas aeruginosa	-	-

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the full-length form is processed to a soluble fragment, which possesses both the GAP and ADP-ribosyltransferase activities	Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor	ExoS is a type III cytotoxin which modulates two eukaryotic signalling pathways. The N-terminus (residues 1-234) is a GTPase activating protein for RhoGTPases, while the C-terminus (residues 232-453) encodes an ADP-ribosyltransferase	Pseudomonas aeruginosa	nicotinamide + (ADP-D-ribosyl)n+1-acceptor	-	?

Synonyms

Synonyms	Comment	Organism
ExoS	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)