Cloned (Comment) | Organism |
---|---|
- |
Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chromatin | TbSIR2RP1 is a nuclear protein that colocalizes with telomeric sequences and minichromosomes | Trypanosoma brucei | 785 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + histone H2A | Trypanosoma brucei | the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair | nicotinamide + (ADP-D-ribosyl)-histone H2A | - |
? | |
NAD+ + histone H2B | Trypanosoma brucei | the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair | nicotinamide + (ADP-D-ribosyl)-histone H2B | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + histone H2A | the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair | Trypanosoma brucei | nicotinamide + (ADP-D-ribosyl)-histone H2A | - |
? | |
NAD+ + histone H2A | the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B | Trypanosoma brucei | nicotinamide + (ADP-D-ribosyl)-histone H2A | - |
? | |
NAD+ + histone H2B | the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair | Trypanosoma brucei | nicotinamide + (ADP-D-ribosyl)-histone H2B | - |
? | |
NAD+ + histone H2B | the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B | Trypanosoma brucei | nicotinamide + (ADP-D-ribosyl)-histone H2B | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAD-dependent ADP-ribosyltransferase | - |
Trypanosoma brucei |
TbSIR2RP1 | - |
Trypanosoma brucei |