Application | Comment | Organism |
---|---|---|
diagnostics | upregulation of UPP1 increases lymph node metastasis risk and is useful as diagnostic, prognostic, and predictive biomarker in thyroid cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene UPP1, quantitative real-time quantitative PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme UPP1 knockdown by siRNA | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-benzylacyclouridine | BAU | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
uridine + phosphate | Homo sapiens | - |
uracil + alpha-D-ribose 1-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16831 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-CPAP cell | - |
Homo sapiens | - |
thyroid cancer cell | UPP1 expression is significantly downregulated in thyroid cancer | Homo sapiens | - |
TPC-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
uridine + phosphate | - |
Homo sapiens | uracil + alpha-D-ribose 1-phosphate | - |
r |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
UPase | - |
Homo sapiens |
UPP1 | - |
Homo sapiens |
uridine phosphorylase 1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | UPP1 expression is significantly downregulated in thyroid cancer | down |
General Information | Comment | Organism |
---|---|---|
malfunction | significant upregulation of UPP1 in thyroid cancer tissues compared with normal thyroid tissues is significantly correlated with lymph node metastasis, tumour stage and tumour size. In the cell, reduced UPP1 expression significantly suppresses the migration, invasion and proliferation. Downregulation of UPP1 gene expression in TPC and BCPAP cells inhibits invasion and induces apoptosis in the thyroid cancer cells. Impact of UPP1 silencing on 5-fluorouracil (5-FU) chemo sensitivity in thyroid cancer cell lines | Homo sapiens |
physiological function | enzyme UPP1 plays an essential role in pyrimidine salvage and regulation of uridine homeostasis. It plays a vital role in the stimulation of pyrimidine nucleoside analogues. UPP1 expression effects on 5-fluorouracil regulates epithelial-mesenchymal transition pathway. UPP1 acts as a crucial oncogene in thyroid cancer regulating epithelial-mesenchymal transition. Upregulation of UPP1 increases lymph node metastasis risk | Homo sapiens |