Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.3 extracted from

  • Roosild, T.; Castronovo, S.
    Active site conformational dynamics in human uridine phosphorylase 1 (2010), PLoS ONE, 5, e12741.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with 5-fluorouridine, to 2.3 A resolution. The dimeric enzyme is capable of a large hinge motion between its two domains, facilitating ligand exchange and explaining observed cooperativity between the two active sites in binding phosphate-bearing substrates. A loop toward the back end of the uracil binding pocket flexibly adjusts to the varying chemistry of different compounds through an ‘induced-fit association mechanism Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16831
-
-

Synonyms

Synonyms Comment Organism
UPP1
-
Homo sapiens