Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.3 extracted from

  • Fujimoto, K.; Matsumura, Y.; Tani, Y.; Ozono, S.; Hirao, Y.; Okajima, E.
    Tissue levels of pyrimidine nucleoside phosphorylase activity in human and rodent bladder cancer and normal bladder tissue (2007), Int. J. Urol., 14, 754-759.
    View publication on PubMed
Search for more literature for 2.4.2.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyrimidine nucleoside + phosphate Rattus norvegicus most pyrimidine nucleosides except for 4-amino-substituted species like deoxycytidine pyrimidine base + alpha-D-ribose 1-phosphate or alpha-D-deoxyribose 1-phosphate r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C3H/He female mice
-
Rattus norvegicus
-
 Fischer 344 male rats
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder N-butyl-N-(4-hydoxybutyl) nitrosamine (BBN) treatment for 12 weeks induces invasive cancer development in mice Mus musculus
-
bladder N-butyl-N-(4-hydoxybutyl) nitrosamine (BBN) treatment for 12 weeks induces superficial cancer development in rats Rattus norvegicus
-
bladder transitional cell carcinoma cell 12 weeks after initiation of BBN treatment: higher PyNpase level in superficial cancer and hyperplasia compared to controls, 16 and 20 weeks after initiation of BBN treatment: higher PyNpase level in superficial cancer but not in hyperplasia compared to controls Rattus norvegicus
-
bladder transitional cell carcinoma cell 12, 16 and 20 weeks after initiation of BBN treatment: higher PyNpase level in invasive carcinoma and hyperplasia compared to controls Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyrimidine nucleoside + phosphate most pyrimidine nucleosides except for 4-amino-substituted species like deoxycytidine Rattus norvegicus pyrimidine base + alpha-D-ribose 1-phosphate or alpha-D-deoxyribose 1-phosphate r
uridine + phosphate
-
 Mus musculus uracil + alpha-D-ribose 1-phosphate
-
 r
uridine + phosphate
-
 Rattus norvegicus uracil + alpha-D-ribose 1-phosphate
-
 r

Synonyms

Synonyms Comment Organism
pynpase
-
 Mus musculus
pynpase
-
 Rattus norvegicus
pyrimidine nucleoside phosphorylase
-
 Mus musculus
pyrimidine nucleoside phosphorylase
-
 Rattus norvegicus
uridine phosphorylase
-
 Mus musculus
uridine phosphorylase
-
 Rattus norvegicus