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Literature summary for 2.4.2.29 extracted from

  • Meyer, E.A.; Donati, N.; Guillot, M.; Schweizer, W.B.; Diederich, F.; Stengl, B.; Brenk, R.; Reuter, K.; Klebe, G.
    Synthesis, biological evaluation, and crystallographic studies of extended guanine-based (lin-benzoguanine) inhibitors for tRNA-guanine transglycosylase (TGT) (2006), Helv. Chim. Acta, 89, 573-597.
No PubMed abstract available
Search for more literature for 2.4.2.29

Inhibitors

Inhibitors Comment Organism Structure
2,6-diaminoquinazolin-4(3H)-one
-
 Zymomonas mobilis
2-amino-8-methylquinazolin-4(3H)-one
-
 Zymomonas mobilis
2-aminopteridin-4(3H)-one
-
 Zymomonas mobilis
2-aminoquinazolin-4(3H)-one
-
 Zymomonas mobilis
4-(2-phenylethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Zymomonas mobilis
6-amino-3-(2-phenylethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Zymomonas mobilis
6-amino-3-benzyl-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Zymomonas mobilis
6-amino-4-(2-phenylethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Zymomonas mobilis
6-amino-4-phenyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Zymomonas mobilis
6-amino-4-[2-(4-methylphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Zymomonas mobilis
6-amino-4-[2-(methoxyphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Zymomonas mobilis
6-aminoimidazol[4,5-g]quinazolin-8(7H)-one
-
 Zymomonas mobilis
additional information design, synthesis, and in vitro evaluation of novel tricyclic TGT inhibitors based on the lin-benzoguanine scaffold Zymomonas mobilis

Organism

Organism UniProt Comment Textmining
Zymomonas mobilis
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0006
-
 2,6-diaminoquinazolin-4(3H)-one 37°C, pH 7.3 Zymomonas mobilis
0.001
-
 6-amino-4-(2-phenylethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one 37°C, pH 7.3, Kic Zymomonas mobilis
0.0017
-
 2-aminoquinazolin-4(3H)-one 37°C, pH 7.3 Zymomonas mobilis
0.0022
-
 2-aminopteridin-4(3H)-one 37°C, pH 7.3 Zymomonas mobilis
0.0028
-
 4-(2-phenylethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one 37°C, pH 7.3 Zymomonas mobilis
0.0037
-
 6-amino-4-[2-(methoxyphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one 37°C, pH 7.3, Kic Zymomonas mobilis
0.0041
-
 6-aminoimidazol[4,5-g]quinazolin-8(7H)-one 37°C, pH 7.3, Kic Zymomonas mobilis
0.0069
-
 6-amino-4-[2-(4-methylphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one 37°C, pH 7.3, Kic Zymomonas mobilis
0.0073
-
 6-amino-3-(2-phenylethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one 37°C, pH 7.3, Kic Zymomonas mobilis
0.0079
-
 6-aminoimidazol[4,5-g]quinazolin-8(7H)-one 37°C, pH7.3, Kiu Zymomonas mobilis
0.015
-
 6-amino-3-benzyl-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one 37°C, pH 7.3, Kic Zymomonas mobilis
0.0191
-
 2-amino-8-methylquinazolin-4(3H)-one 37°C, pH 7.3 Zymomonas mobilis
0.029
-
 6-amino-4-phenyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one 37°C, pH 7.3, Kic Zymomonas mobilis