Literature summary for 2.4.2.28 extracted from

Basu, I.; Cordovano, G.; Das, I.; Belbin, T.J.; Guha, C.; Schramm, V.L.
A transition state analogue of 5-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers (2007), J. Biol. Chem., 282, 21477-21486.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(3R,4S)-1-[(9-deazaadenin-9yl)methyl]-3-hydroxy-4-(methylthio-methyl) pyrrolidine	treatment of cultured FaDu and Cal27 cells with 0.001 mM (3R,4S)-1-[(9-deazaadenin-9yl)methyl]-3-hydroxy-4-(methylthio-methyl) pyrrolidine and 0.02 mM 5'-methylthioadenosine inhibits MTAP by 96%, increases cellular 5'-methylthioadenosine concentrations, decreases polyamines, and induces apoptosis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BJ cell	-	Homo sapiens	-
Cal27 cell	-	Homo sapiens	-
FaDu cell	-	Homo sapiens	-
GM02037 cell	-	Homo sapiens	-
HNSCC cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
additional information	no expression in MCF-7, A-549, or U-87 cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5'-methylthioadenosine + phosphate	-	Homo sapiens	adenine + 5-methylthio-D-ribose 1-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
methylthioadenosine phosphorylase	-	Homo sapiens
MTAP	-	Homo sapiens

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Release 2023.1 (January 2023)