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Literature summary for 2.4.2.28 extracted from
- Structural analogs of 5'-methylthioadenosine as substrates and inhibitors of 5'-methylthioadenosine phosphorylase and as inhibitors of human lymphocyte transformation (1982), Biochem. Pharmacol., 31, 503-507.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5'-deoxy-5'-methylthiotubercidin | - |
Homo sapiens |  |
| 5'-methylthiotubercidin | - |
Homo sapiens | |
| adenine | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.023 | - |
5'-deoxyadenosine | - |
Homo sapiens | |
| 0.026 | - |
5'-deoxy-5'-methylthioadenosine | - |
Homo sapiens | |
| 7.5 | - |
phosphate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lymphocyte | peripheral blood | Homo sapiens | - |
| peripheral blood | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5'-deoxy-5'-methylthioadenosine + phosphate | - |
Homo sapiens | adenine + 5-methylthio-D-ribose 1-phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 47 | - |
- |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.031 | - |
5'-methylthiotubercidin | - |
Homo sapiens | |
| 0.172 | - |
adenine | - |
Homo sapiens | |
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