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Literature summary for 2.4.2.28 extracted from

  • Savarese, T.M.; Harrington, S.; Nakamura, C.; Chen, Z.H.; Kumar, P.; Mikkilineni, A.; Abushanab, E.; Chu, S.H.; Parks, R.E.
    5'-Deoxy-5'-methylthioadenosine phosphorylase. V. Acycloadenosine derivatives as inhibitors of the enzyme (1990), Biochem. Pharmacol., 40, 2465-2471.
    View publication on PubMed
Search for more literature for 2.4.2.28

Inhibitors

Inhibitors Comment Organism Structure
2-bromo-9-(1,3-dihydroxy-2-propoxymethyl)adenine strong Mus musculus
2-bromo-9-(2-hydroxyethoxymethyl)adenine
-
 Mus musculus
2-chloro-9-(1,3-dihydroxy-2-propoxymethyl)adenine strong Mus musculus
2-chloro-9-(2-hydroxyethoxymethyl)adenine
-
 Mus musculus
2-iodo-9-(1,3-dihydroxy-2-propoxymethyl)adenine strong Mus musculus
2-iodo-9-(2-hydroxyethoxymethyl)adenine
-
 Mus musculus
9-(phosphonoalkyl)adenine
-
 Mus musculus
9-(phosphonoheptyl)adenine
-
 Mus musculus
9-[(1-Hydroxy-3-iodo-2-propoxy)methyl]adenine
-
 Homo sapiens
9-[(1-Hydroxy-3-iodo-2-propoxy)methyl]adenine competitive Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-methylthioadenosine + phosphate Mus musculus involved in salvage of adenine and methionine from 5'-methylthioadenosine adenine + 5-methylthio-D-ribose 1-phosphate
-
 ?
5'-methylthioadenosine + phosphate Homo sapiens involved in salvage of adenine and methionine from 5'-methylthioadenosine adenine + 5-methylthio-D-ribose 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CCRF S-180 II cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-methylthioadenosine + phosphate involved in salvage of adenine and methionine from 5'-methylthioadenosine Mus musculus adenine + 5-methylthio-D-ribose 1-phosphate
-
 ?
5'-methylthioadenosine + phosphate involved in salvage of adenine and methionine from 5'-methylthioadenosine Homo sapiens adenine + 5-methylthio-D-ribose 1-phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002 0.0007 2-bromo-9-(1,3-dihydroxy-2-propoxymethyl)adenine
-
 Mus musculus
0.0002 0.0007 2-chloro-9-(1,3-dihydroxy-2-propoxymethyl)adenine
-
 Mus musculus
0.0002 0.0007 2-iodo-9-(1,3-dihydroxy-2-propoxymethyl)adenine
-
 Mus musculus
0.001 0.01 2-bromo-9-(2-hydroxyethoxymethyl)adenine
-
 Mus musculus
0.001 0.01 2-chloro-9-(2-hydroxyethoxymethyl)adenine
-
 Mus musculus
0.001 0.01 2-iodo-9-(2-hydroxyethoxymethyl)adenine
-
 Mus musculus
0.015
-
 9-(phosphonoheptyl)adenine low phosphate concentration of 3.5 mM Mus musculus