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Literature summary for 2.4.2.26 extracted from

  • Poenighaus, C.; Ambrosius, M.; Casanova, J.C.; Prante, C.; Kuhn, J.; Esko, J.D.; Kleesiek, K.; Goetting, C.
    Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans (2007), J. Biol. Chem., 282, 5201-5206.
    View publication on PubMed
Search for more literature for 2.4.2.26

Cloned(Commentary)

Cloned (Comment) Organism
expressed in xylosyltransferase-deficient pgsA-745 CHO cells Homo sapiens
expression in Pichia pastoris. Transfection of the xylosyltransferase-deficient Chinese hamster ovary mutant pgsA-745 with XT-II coding cDNA completely restores glycosaminoglycan biosynthesis Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0052
-
 biotin-NH-QEEEGSGGGQKK(5-fluorescein)-CONH2
-
 Homo sapiens
0.0052
-
 biotin-NHQEEEGSGGGQKK(5-fluorescein)-CONH2 recombinant enzyme Homo sapiens
0.022
-
 bikunin
-
 Homo sapiens
0.022
-
 bikunin recombinant enzyme Homo sapiens
0.062
-
 fibroblast growth factor 2 recombinant enzyme Homo sapiens
0.677
-
 silk fibroin
-
 Homo sapiens
0.677
-
 silk fibroin recombinant enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secreted into the culture supernatant Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans ?
-
 ?
additional information Homo sapiens XT-II initiates the biosynthesis of both heparan sulfate and chondroitin sulfate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q9H1B5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture supernatant
-
 Homo sapiens
-
kidney XT-I and XT-II are highly expressed in kidney Homo sapiens
-
liver XT-II is highly expressed in liver, no XT-I mRNA is detectable in liver Homo sapiens
-
lung XT-II is highly expressed in lung Homo sapiens
-
testis XT-I is highly expressed in testes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans Homo sapiens ?
-
 ?
additional information XT-II initiates the biosynthesis of both heparan sulfate and chondroitin sulfate Homo sapiens ?
-
 ?
UDP-D-xylose + bikunin
-
 Homo sapiens UDP + D-xylosyl-bikunin
-
 ?
UDP-D-xylose + bikunin
-
 Homo sapiens ?
-
 ?
UDP-D-xylose + biotin-NH-QEEEGSGGGQKK(5-fluorescein)-CONH2 best substrate known so far for XT-IImediated xylosylation Homo sapiens UDP + biotin-NH-QEEEGS(D-xylosyl)GGGQKK(5-fluorescein)-CONH2
-
 ?
UDP-D-xylose + biotin-NHQEEEGSGGGQKK(5-fluorescein)-CONH2 biotin-NHQEEEGSGGGQKK(5-fluorescein)-CONH2is the best acceptor for isozyme XT-II Homo sapiens UDP + biotin-NHQEEEG-(D-xylosyl)SGGGQKK(5-fluorescein)-CONH2
-
 ?
UDP-D-xylose + fibroblast growth factor 2
-
 Homo sapiens ?
-
 ?
UDP-D-xylose + silk fibroin silk fibroin is a low affinity acceptor for XT-II Homo sapiens UDP + silk fibroin with xylosylserine
-
 ?
UDP-D-xylose + silk fibroin
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase
-
 Homo sapiens
XT-II
-
 Homo sapiens
xylosyltransferase II
-
 Homo sapiens