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Literature summary for 2.4.2.26 extracted from
- Xylosylation of alternatively spliced isoforms of Alzheimer APP by xylosyltransferase (1998), J. Protein Chem., 17, 295-302.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0006 | - |
bikunin | recombinant mutant bikunin | Homo sapiens | |
| 0.019 | - |
SENEGSGMAEQK | - |
Homo sapiens |  |
| 0.019 | - |
SENEGSGMAQQK | - |
Homo sapiens | |
| 0.02 | - |
TENEGSGLTNIK | - |
Homo sapiens | |
| 0.022 | - |
bikunin-derived aminoterminus homologous peptide | - |
Homo sapiens | |
| 0.022 | - |
QEEEGSGGGQK | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| extracellular | human cell cultures | Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
Lewis1WR1 | - |
| Rattus norvegicus Lewis1WR1 | - |
Lewis1WR1 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| cartilage | - |
Rattus norvegicus | - |
| cartilage | sternal, from heart | Homo sapiens | - |
| cerebrospinal fluid | - |
Homo sapiens | - |
| chondrocyte | from heart sternal cartilage | Homo sapiens | - |
| chondrocyte | cell culture supernatant | Homo sapiens | - |
| heart | - |
Rattus norvegicus | - |
| heart | sternal cartilage | Homo sapiens | - |
| JAR cell | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Rattus norvegicus | - |
| additional information | activity in several human cell lines, culture supernatant, overview | Homo sapiens | - |
| ovary | low activity | Rattus norvegicus | - |
| serum | - |
Homo sapiens | - |
| serum | from heart blood | Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
| thyroid gland | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity in several tissues, overview | Rattus norvegicus |
| additional information | - |
activity in several human cell lines, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-xylose + [protein]-L-serine | transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate | Homo sapiens | UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine | - |
? | |
| UDP-alpha-D-xylose + [protein]-L-serine | transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate | Rattus norvegicus | UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine | - |
? | |
| UDP-alpha-D-xylose + [protein]-L-serine | transfers a beta-D-xylosyl residue to specific serine residues dependent on the consensus signal sequence | Homo sapiens | UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine | - |
? | |
| UDP-alpha-D-xylose + [protein]-L-serine | transfers a beta-D-xylosyl residue to specific serine residues dependent on the consensus signal sequence | Rattus norvegicus | UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine | - |
? | |
| UDP-alpha-D-xylose + [protein]-L-serine | transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate | Rattus norvegicus Lewis1WR1 | UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine | - |
? | |
| UDP-alpha-D-xylose + [protein]-L-serine | transfers a beta-D-xylosyl residue to specific serine residues dependent on the consensus signal sequence | Rattus norvegicus Lewis1WR1 | UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine | - |
? | |
| UDP-D-xylose + bikunin | recombinant mutant bikunin | Rattus norvegicus | UDP + D-xylosyl-bikunin | - |
? | |
| UDP-D-xylose + bikunin | recombinant mutant bikunin | Homo sapiens | UDP + D-xylosyl-bikunin | bound to serine residue | ? | |
| UDP-D-xylose + bikunin | recombinant mutant bikunin | Rattus norvegicus Lewis1WR1 | UDP + D-xylosyl-bikunin | - |
? | |
| UDP-D-xylose + bikunin-derived aminoterminus homologous peptide | - |
Homo sapiens | UDP + xylosyl-serine bikunin-derived aminoterminus homologous peptide | - |
? | |
| UDP-D-xylose + QEEEGSGGGQK | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-D-xylose + SENEGSGMAEQK | synthetic leukocyte-derived amyloid precursor-like protein homologous peptide | Homo sapiens | UDP + SENEGS(-D-xylose)GMAEQK | - |
? | |
| UDP-D-xylose + SENEGSGMAQQK | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-D-xylose + TENEGSGLTNIK | synthetic leukocyte-derived beta-A4-amyloid protein precursor homologous peptide | Homo sapiens | UDP + TENEGS(-D-xylose)GLTNIK | - |
? | |
| UDP-D-xylose + TENEGSGLTNIK | - |
Homo sapiens | UDP + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| XT | - |
Homo sapiens |
| XT | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Homo sapiens |
| 6.5 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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