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Literature summary for 2.4.2.22 extracted from

  • Zarella-Boitz, J.M.; Rager, N.; Jardim, A.; Ullman, B.
    Subcellular localization of adenine and xanthine phosphoribosyltransferases in Leishmania donovani (2004), Mol. Biochem. Parasitol., 134, 43-51.
    View publication on PubMed
Search for more literature for 2.4.2.22

Cloned(Commentary)

Cloned (Comment) Organism
expression of full length and C-terminally truncated enzymes in Escherichia coli Leishmania donovani

Protein Variants

Protein Variants Comment Organism
additional information deletion of the glycosomal targeting sequence, a C-terminal tripeptide, leads to mislocation of the enzyme in the cytosol, where the enzyme nevertheless is still active Leishmania donovani

Localization

Localization Comment Organism GeneOntology No. Textmining
glycosome deletion of the glycosomal targeting sequence, a C-terminal tripeptide, leads to mislocation of the enzyme in the cytosol, where the enzyme nevertheless is still active Leishmania donovani 20015
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additional information immunohistologic subcellular localization study Leishmania donovani
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-
peroxisome deletion of the peroxisomal targeting sequence is not required for activity Leishmania donovani 5777
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-phospho-alpha-D-ribose 1-diphosphate + xanthine Leishmania donovani the enzyme is involved in purine nucleotide synthesis via phosphorylation of purines acquisited from the host, since Leishmania donovani is not able to perform de novo biosynthesis of purine nucleotides 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania donovani
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-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant full length and C-terminally truncated enzymes from Escherichia coli by affinity chromatography Leishmania donovani

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
-
 Leishmania donovani 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine the enzyme is involved in purine nucleotide synthesis via phosphorylation of purines acquisited from the host, since Leishmania donovani is not able to perform de novo biosynthesis of purine nucleotides Leishmania donovani 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
xanthine PRT
-
 Leishmania donovani
XPRT
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 Leishmania donovani