General Stability | Organism |
---|---|
increase in potassium phosphate buffer concentration from 1-50 mM increases stability | Enterococcus faecalis |
stabilizing compounds are: 5-phospho-alpha-D-ribose 1-diphosphate, XMP, 6-oxo-substituted purine nucleotides | Enterococcus faecalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-Methylxanthine | - |
Enterococcus faecalis | |
2,4-dihydroxy-5,6-tetramethylenepyrimidine | - |
Enterococcus faecalis | |
2,4-Dihydroxypteridine | - |
Enterococcus faecalis | |
2,4-dihydroxypyrido[2,3-d]pyrimidine | - |
Enterococcus faecalis | |
2,4-dihydroxypyrido[3,2-d]pyrimidine | - |
Enterococcus faecalis | |
2,4-dihydroxypyrido[3,4-d]pyrimidine | - |
Enterococcus faecalis | |
2,4-dihydroxypyrrolo[2,3-d]pyrimidine | - |
Enterococcus faecalis | |
2,6-dithioxanthine | - |
Enterococcus faecalis | |
2-hydroxy-6-methylthiopurine | - |
Enterococcus faecalis | |
2-Hydroxypurine | - |
Enterococcus faecalis | |
2-mercaptopurine | - |
Enterococcus faecalis | |
2-methylhypoxanthine | - |
Enterococcus faecalis | |
2-methylthio-6-hydroxypurine | - |
Enterococcus faecalis | |
2-Thioxanthine | - |
Enterococcus faecalis | |
3-Methylxanthine | - |
Enterococcus faecalis | |
4,6-dihydroxypyrazolo[3,4-d]-pyrimidine | - |
Enterococcus faecalis | |
4-aminoimidazole-5-carboxamide | - |
Enterococcus faecalis | |
4-hydroxypyrazolo[3,4-d]pyrimidine | - |
Enterococcus faecalis | |
4-mercapto-6-hydroxypyrazolo[3,4-d]pyrimidine | - |
Enterococcus faecalis | |
4-mercaptopyrazolo[3,4-d]pyrimidine | - |
Enterococcus faecalis | |
5,7-dihydroxy(1,2,5)thiadiazolo[3,4-d]pyrimidine | - |
Enterococcus faecalis | |
5,7-dihydroxy-v-triazolo[4,5-d]pyrimidine | - |
Enterococcus faecalis | |
5,7-dihydroxypyrazolo[4,3-d]pyrimidine | - |
Enterococcus faecalis | |
5-acetamidouracil | - |
Enterococcus faecalis | |
5-Aminouracil | - |
Enterococcus faecalis | |
5-anilinouracil | - |
Enterococcus faecalis | |
5-formamidouracil | - |
Enterococcus faecalis | |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Enterococcus faecalis | |
6-Mercaptopurine | - |
Enterococcus faecalis | |
6-Thioxanthine | - |
Enterococcus faecalis | |
7-methylxanthine | - |
Enterococcus faecalis | |
8-mercaptoxanthine | - |
Enterococcus faecalis | |
8-methylxanthine | - |
Enterococcus faecalis | |
9-methylxanthine | - |
Enterococcus faecalis | |
adenine | - |
Enterococcus faecalis | |
ATP | 1 mM, 11% inhibition | Enterococcus faecalis | |
CDP | 1 mM, 10% inhibition | Enterococcus faecalis | |
CTP | 1 mM, 27% inhibition | Enterococcus faecalis | |
GDP | 1 mM, 93 inhibition | Enterococcus faecalis | |
GMP | 1 mM, 89% inhibition | Enterococcus faecalis | |
GTP | 1 mM, 91% inhibition | Enterococcus faecalis | |
guanine | - |
Enterococcus faecalis | |
hypoxanthine | - |
Enterococcus faecalis | |
isoguanine | - |
Enterococcus faecalis | |
purine | - |
Enterococcus faecalis | |
TDP | 1 mM, 18% inhibition | Enterococcus faecalis | |
TTP | 1 mM, 13% inhibition | Enterococcus faecalis | |
UDP | 1 mM, 15% inhibition | Enterococcus faecalis | |
Uracil | - |
Enterococcus faecalis | |
uric acid | - |
Enterococcus faecalis | |
UTP | 1 mM, 17% inhibition | Enterococcus faecalis | |
xanthine | - |
Enterococcus faecalis | |
XDP | 1 mM, 89% inhibition | Enterococcus faecalis | |
XMP | 1 mM, 92% inhibition | Enterococcus faecalis | |
XTP | 1 mM, 92% inhibition | Enterococcus faecalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.019 | - |
5,7-dihydroxy-v-triazolo[4,5-d]pyrimidine | - |
Enterococcus faecalis | |
0.02 | - |
xanthine | - |
Enterococcus faecalis | |
0.053 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Enterococcus faecalis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
gel filtration | Enterococcus faecalis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterococcus faecalis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Enterococcus faecalis |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
3.65 | - |
- |
Enterococcus faecalis |
Storage Stability | Organism |
---|---|
-70°C, stable for 6 months in intacts cells | Enterococcus faecalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-phospho-alpha-D-ribose 1-diphosphate + 4,6-dihydroxypyrazolo[3,4-d]pyrimidine | at 0.064% of the activity with xanthine | Enterococcus faecalis | ? | - |
? | |
5-phospho-alpha-D-ribose 1-diphosphate + 5,7-dihydroxy-v-triazolo[4,5-d]pyrimidine | at 16.8% of the activity with xanthine | Enterococcus faecalis | ? | - |
? | |
5-phospho-alpha-D-ribose 1-diphosphate + adenine | at 0.25% of the activity with xanthine | Enterococcus faecalis | AMP + diphosphate | - |
? | |
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine | at 0.19% of the activity with xanthine | Enterococcus faecalis | IMP + diphosphate | - |
? | |
5-phospho-alpha-D-ribose 1-diphosphate + xanthine | - |
Enterococcus faecalis | 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
pH 5.6-10, stable for 30 min | Enterococcus faecalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | 8.8 | - |
Enterococcus faecalis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.9 | 9.1 | 80% of maximal activity at pH 6.9 and 9.1 | Enterococcus faecalis |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
5.6 | 10 | stable | Enterococcus faecalis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0022 | - |
5,7-dihydroxypyrazolo[4,3-d]pyrimidine | - |
Enterococcus faecalis | |
0.0041 | - |
2,4-dihydroxypyrido[3,2-d]pyrimidine | - |
Enterococcus faecalis | |
0.021 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Enterococcus faecalis | |
0.024 | - |
xanthine | - |
Enterococcus faecalis | |
0.024 | - |
2,4-Dihydroxypteridine | - |
Enterococcus faecalis | |
0.032 | - |
5,7-dihydroxy(1,2,5)thiadiazolo[3,4-d]pyrimidine | - |
Enterococcus faecalis | |
0.11 | - |
5,7-dihydroxy-v-triazolo[4,5-d]pyrimidine | - |
Enterococcus faecalis | |
0.15 | - |
2,6-dithioxanthine | - |
Enterococcus faecalis | |
0.17 | - |
2-hydroxy-6-methylthiopurine | - |
Enterococcus faecalis | |
0.2 | - |
4-mercapto-6-hydroxypyrazolo[3,4-d]pyrimidine | - |
Enterococcus faecalis | |
0.31 | - |
4,6-dihydroxypyrazolo[3,4-d]-pyrimidine | - |
Enterococcus faecalis | |
0.34 | - |
6-Thioxanthine | - |
Enterococcus faecalis | |
0.38 | - |
2-Thioxanthine | - |
Enterococcus faecalis | |
0.39 | - |
8-mercaptoxanthine | - |
Enterococcus faecalis | |
0.62 | - |
3-Methylxanthine | - |
Enterococcus faecalis |