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Literature summary for 2.4.2.21 extracted from

  • Cheong, C.G.; Escalante-Semerena, J.C.; Rayment, I.
    Capture of a labile substrate by expulsion of water molecules from the active site of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella enterica (2002), J. Biol. Chem., 277, 41120-41127.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with different substrate analogs, reaction pathway Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinic acid mononucleotide + benzimidazole Salmonella enterica
-
 1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinic acid alpha-ribazole 5'-phosphate ?
nicotinic acid mononucleotide + benzimidazole Salmonella enterica
-
 1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinic acid intermediate for the lower ligand of cobalamin ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
-
-

Reaction

Reaction Comment Organism Reaction ID
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate + H+ mechanism Salmonella enterica
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinic acid mononucleotide + benzimidazole
-
 Salmonella enterica 1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinate
-
 ?
nicotinic acid mononucleotide + benzimidazole
-
 Salmonella enterica 1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinic acid alpha-ribazole 5'-phosphate ?
nicotinic acid mononucleotide + benzimidazole
-
 Salmonella enterica 1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinic acid intermediate for the lower ligand of cobalamin ?