Literature summary for 2.4.2.19 extracted from

Wang, Z.; Gao, Y.; Zhang, C.; Hu, H.; Guo, D.; Xu, Y.; Xu, Q.; Zhang, W.; Deng, S.; Lv, P.; Yang, Y.; Ding, Y.; Li, Q.; Weng, C.; Chen, X.; Gong, S.; Chen, H.; Niu, J.; Tang, H.
Quinolinate phosphoribosyltransferase is an antiviral host factor against hepatitis C virus infection (2017), Sci. Rep., 7, 5876 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
Clofibrate	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate	Homo sapiens	-	beta-nicotinate D-ribonucleotide + diphosphate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q15274	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	-	Homo sapiens	-
Huh-7.5.1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate	-	Homo sapiens	beta-nicotinate D-ribonucleotide + diphosphate + CO2	-	?

Subunits

Subunits	Comment	Organism
?	x * 35000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
QPRT	-	Homo sapiens
quinolinate phosphoribosyltransferase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme is significantly reduced in livers of patients with persistent hepatitis C virus infection	down

General Information

General Information	Comment	Organism
physiological function	the enzyme inhibits hepatitis C virus replication via reduction of cellular lipogenesis	Homo sapiens

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Release 2023.1 (January 2023)