Crystallization (Comment) | Organism |
---|---|
apoenzyme and in complex with quinolinic acid or nicotinic acid mononucleotide, hanging drop vapor diffusion method, using | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R161A | the mutation abolishes substrate binding and enzyme activity with a 20% capacity of wild type enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
nicotinic acid mononucleotide + diphosphate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15274 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | nicotinic acid mononucleotide + diphosphate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
hexamer | x-ray crystallography | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
QPRT | - |
Homo sapiens |
quinolinate phosphoribosyltransferase | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
83.6 | - |
melting temperature | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is essential for maintaining the homeostasis of quinolinic acid in the brain | Homo sapiens |