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Literature summary for 2.4.2.19 extracted from

  • Taguchi, H.; Iwai, K.
    Inhibition of hog liver crystalline quinolinate phosphoribosyltransferase by nucleotides, quinolinate analogues and sulfhydryl reagents (1976), Agric. Biol. Chem., 40, 385-389.
No PubMed abstract available
Search for more literature for 2.4.2.19

Inhibitors

Inhibitors Comment Organism Structure
ADP 2 mM, 25% inhibition Sus scrofa
AMP 2 mM, 7% inhibition Sus scrofa
ATP 2 mM, 82% inhibition; inhibition is removed by raising Mg2+ concentrations Sus scrofa
CDP 2 mM, 20% inhibition Sus scrofa
CTP 2 mM, 77% inhibition Sus scrofa
dipicolinic acid 1 mM, 24% inhibition Sus scrofa
dithiobis(2-nitrobenzoic acid) 10 mM, 88.7% inhibition Sus scrofa
GDP 2 mM, 29% inhibition Sus scrofa
GTP 2 mM, 77% inhibition Sus scrofa
IDP 2 mM, 29% inhibition Sus scrofa
IMP 2 mM, 6% inhibition Sus scrofa
isocinchomeric acid 1 mM, 15% inhibition Sus scrofa
ITP 2 mM, 81% inhibition Sus scrofa
lutidinic acid 1 mM, 17% inhibition Sus scrofa
Monoiodoacetic acid 50 mM, 99.8% inhibition Sus scrofa
NEM 5 mM, 86% inhibition Sus scrofa
PCMB 0.05 mM, complete inhibition Sus scrofa
Phthalic acid competitive to quinolinate Sus scrofa
UDP 2 mM, 32% inhibition Sus scrofa
UTP 2 mM, 74% inhibition Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement. Optimal concentration is 1 mM in absence of ATP and 7 mM in presence of ATP at 5 mM Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa intermediary enzyme in the de novo NAD biosynthetic pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information intermediary enzyme in the de novo NAD biosynthetic pathway Sus scrofa ?
-
 ?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Sus scrofa nicotinate D-ribonucleotide + diphosphate + CO2
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.17
-
 Phthalic acid
-
 Sus scrofa