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Literature summary for 2.4.2.18 extracted from

  • Ramos, I.; Downs, D.M.
    Anthranilate synthase can generate sufficient phosphoribosyl amine for thiamine synthesis in Salmonella enterica (2003), J. Bacteriol., 185, 5125-5132.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.18

Protein Variants

Protein Variants Comment Organism
P362L mutation in enzyme complex subunit TrpD, increased activity compared to the wild-type enzyme Salmonella enterica

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica generation of phosphoribosyl amine from 5-phospho-alpha-D-ribose 1-diphosphate is a step in thiamine biosynthesis N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
additional information Salmonella enterica connections between purine, thiamine, and tryptophan biosynthetic pathways, overview, the enzyme complex can substitute for PurF in formation of phosphoribosyl amine in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ammonia + 5-phospho-alpha-D-ribose 1-diphosphate anthranilate synthase-phosphoribosyl transferase complex subunit TrpD in vitro Salmonella enterica phosphoribosyl amine + diphosphate
-
 ?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate generation of phosphoribosyl amine from 5-phospho-alpha-D-ribose 1-diphosphate is a step in thiamine biosynthesis Salmonella enterica N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate reaction is catalyzed by the TrpD subunit of the anthranilate synthase-phosphoribosyl transferase complex Salmonella enterica N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
additional information connections between purine, thiamine, and tryptophan biosynthetic pathways, overview, the enzyme complex can substitute for PurF in formation of phosphoribosyl amine in vivo Salmonella enterica ?
-
 ?

Synonyms

Synonyms Comment Organism
anthranilate phosphoribosyl transferase
-
 Salmonella enterica
More enzyme is component II of the anthranilate synthase-phosphoribosyl transferase complex Salmonella enterica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at, formation of N-(5-phospho-D-ribosyl)-anthranilate Salmonella enterica