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Literature summary for 2.4.2.18 extracted from

  • Grieshaber, M.
    On the evolution of a oligocephalic enzyme. Glutamine-chorismate-amidotransferase-free anthranilate phosphoribosyltransferases from mutant strains of Salmonella typhimurium (1978), Z. Naturforsch. C, 33c, 235-244.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
L-tryptophan
-
Salmonella enterica subsp. enterica serovar Typhimurium
N-(5-phospho-D-ribosyl)-anthranilate
-
Salmonella enterica subsp. enterica serovar Typhimurium
Sodium diphosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
anthranilate TAX6trpR782 Salmonella enterica subsp. enterica serovar Typhimurium
0.004
-
anthranilate trpAB1653trpR782 Salmonella enterica subsp. enterica serovar Typhimurium
0.013
-
5-phospho-alpha-D-ribose 1-diphosphate TAX6trpR782 Salmonella enterica subsp. enterica serovar Typhimurium
0.06
-
5-phospho-alpha-D-ribose 1-diphosphate trpAB1653trpR782 Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
x * 72000, strain trpAB1653trpR782, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
220000
-
and larger than 1000000, strain trpAB1653trpR782, gel filtration Salmonella enterica subsp. enterica serovar Typhimurium
320000
-
strain TAX6trpR782, gel filtration Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica subsp. enterica serovar Typhimurium enzyme of tryptophan biosynthesis N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
strains: trp+, TAX6trpR782, trpA703trpR782 and trpAB1653trpR782
-

Purification (Commentary)

Purification (Comment) Organism
enzyme complex, homogeneity Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
0.5
-
strain TAX6trpR782 and trpAB165trpR782 Salmonella enterica subsp. enterica serovar Typhimurium
2.7
-
strain trpA703trpR782 Salmonella enterica subsp. enterica serovar Typhimurium
3.2
-
strain trp+ Salmonella enterica subsp. enterica serovar Typhimurium
17.6
-
strain trpAB1653 Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate enzyme of tryptophan biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
?

Subunits

Subunits Comment Organism
? x * 72000, strain trpAB1653trpR782, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
More enzyme complex is a tetramer composed of 2 molecules each of component II and II Salmonella enterica subsp. enterica serovar Typhimurium

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
46
-
half-life: strain TAX6trpR782: 1.5 min, strain trpAB1653trpR782: 5 min Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.9
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
7
-
assay at Salmonella enterica subsp. enterica serovar Typhimurium