Literature summary for 2.4.2.17 extracted from

Dall-Larsen, T.; Kryvi, H.; Klungsoyr, L.
Dinitrophenol, dicoumarol and pentachlorophenol as inhibitors and parasite substrates in the ATP phosphoribosyltransferase reaction (1976), Eur. J. Biochem., 66, 443-446.

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Inhibitors

Inhibitors	Comment	Organism	Structure
dicoumarol	competitive with respect to ATP, inhibitor in both directions, diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate	Escherichia coli
dinitrophenol	diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate	Escherichia coli
L-histidine	feed-back inhibition	Escherichia coli
additional information	carbonylcyanide m-chlorophenylhydrazone, which is a potent inhibitor of several enzymes with adenine-containing substrates or coenzymes has no effect	Escherichia coli
Pentachlorophenol	competitive to ATP, inhibitor in both directions, diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate	Escherichia coli	first step in histidine biosynthesis	diphosphate + N-1-(5'-phosphoribosyl)-ATP	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate	-	Escherichia coli	1-(5-phospho-D-ribosyl)-ATP + diphosphate	-	r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate	first step in histidine biosynthesis	Escherichia coli	diphosphate + N-1-(5'-phosphoribosyl)-ATP	-	?

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Release 2023.1 (January 2023)