Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-Ribosyluracil | 1 mM, about 85% inhibition | Canis lupus familiaris | |
2-thio-6-oxopurine | 1 mM, 73% inhibition | Canis lupus familiaris | |
2-Thiouracil | 1 mM, 96% inhibition | Canis lupus familiaris | |
4-amino-5-imidazolecarboxamide | 1 mM, about 15% inhibition | Canis lupus familiaris | |
5-methyluracil | 1 mM, about 90% inhibition | Canis lupus familiaris | |
5-methyluridine | 1 mM, about 95% inhibition | Canis lupus familiaris | |
Colchicine | 1 mM, 43% inhibition, competitive | Canis lupus familiaris | |
guanosine | 1 mM, about 20% inhibition | Canis lupus familiaris | |
Inosine | 1 mM, about 25% inhibition | Canis lupus familiaris | |
p-chloromercuribenzoate | reversed by cysteine | Canis lupus familiaris | |
Phenylbutazone | 1 mM, 30% inhibition, competitive | Canis lupus familiaris | |
Uracil | 1 mM, about 85% inhibition | Canis lupus familiaris | |
xanthine | 1 mM, 35% inhibition | Canis lupus familiaris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
uric acid ribonucleoside + phosphate | Cavia porcellus | - |
urate + D-ribose 1-phosphate | - |
? | |
uric acid ribonucleoside + phosphate | Rattus norvegicus | - |
urate + D-ribose 1-phosphate | - |
? | |
uric acid ribonucleoside + phosphate | Pigeon | - |
urate + D-ribose 1-phosphate | - |
? | |
uric acid ribonucleoside + phosphate | Canis lupus familiaris | - |
urate + D-ribose 1-phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Cavia porcellus | - |
- |
- |
Pigeon | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Canis lupus familiaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Cavia porcellus | - |
heart | - |
Rattus norvegicus | - |
heart | - |
Pigeon | - |
kidney | - |
Cavia porcellus | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Pigeon | - |
kidney | - |
Canis lupus familiaris | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Pigeon | - |
skeletal muscle | - |
Rattus norvegicus | - |
small intestine mucosa | - |
Rattus norvegicus | - |
small intestine mucosa | - |
Pigeon | - |
small intestine mucosa | - |
Canis lupus familiaris | - |
spleen | low activity | Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
testis | - |
Pigeon | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
4.6 | - |
- |
Canis lupus familiaris |
Storage Stability | Organism |
---|---|
-10°C, partially purified enzyme is stable for at least 2 months | Canis lupus familiaris |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
uric acid ribonucleoside + arsenate | - |
Cavia porcellus | urate + D-ribose 1-phosphate | - |
? | |
uric acid ribonucleoside + arsenate | - |
Rattus norvegicus | urate + D-ribose 1-phosphate | - |
? | |
uric acid ribonucleoside + arsenate | - |
Pigeon | urate + D-ribose 1-phosphate | - |
? | |
uric acid ribonucleoside + arsenate | reverse reaction not demonstrated, arsenate can replace phosphate at a lower reaction rate | Canis lupus familiaris | urate + D-ribose 1-phosphate | - |
ir | |
uric acid ribonucleoside + phosphate | - |
Cavia porcellus | urate + D-ribose 1-phosphate | - |
? | |
uric acid ribonucleoside + phosphate | - |
Rattus norvegicus | urate + D-ribose 1-phosphate | - |
? | |
uric acid ribonucleoside + phosphate | - |
Pigeon | urate + D-ribose 1-phosphate | - |
? | |
uric acid ribonucleoside + phosphate | - |
Canis lupus familiaris | urate + D-ribose 1-phosphate | - |
ir |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
pH 7.8, 5 min, 5% loss of activity, partially purified enzyme | Canis lupus familiaris |
60 | - |
pH 7.8, 5 min, 40% loss of activity, partially purified enzyme | Canis lupus familiaris |
70 | - |
pH 7.8, 5 min, 95% loss of activity, partially purified enzyme | Canis lupus familiaris |
80 | - |
pH 7.8, 5 min, 100% loss of activity, partially purified enzyme | Canis lupus familiaris |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | reaction with phosphate or arsenate | Canis lupus familiaris |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 9.5 | pH 6.0: about 60% of maximal activity, pH 9.5: 45% of maximal activity | Canis lupus familiaris |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
0°C, 10 min, 30% loss of activity, partially purified enzyme | Canis lupus familiaris |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.23 | - |
Colchicine | 37°C, pH 8.2 | Canis lupus familiaris | |
1.76 | - |
Phenylbutazone | 37°C, pH 8.2 | Canis lupus familiaris |