Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AMP | competitive vs. 5-phospho-alpha-D-ribose 1-diphosphate, noncompetitive vs. glutamine | Mus musculus | |
piritrexim | noncompetitive vs. 5-phospho-alpha-D-ribose 1-diphosphate, binds with positive cooperativity at 2 allosteric sites of an inactive dimer | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
partially purified enzyme shows 3 molecular forms: an inactive tetramer formed in the presence of AMP, an active dimer formed with 5-phospho-alpha-D-ribose 1-diphosphate and an inactive dimer formed with piritrexim | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukemia cell | L1210 leukemia cells | Mus musculus | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | - |
AMP | - |
Mus musculus | |
0.066 | - |
piritrexim | - |
Mus musculus |