Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.12 extracted from

  • Kong, J.; Du, C.; Jiang, L.; Jiang, W.; Deng, P.; Shao, X.; Zhang, B.; Li, Y.; Zhu, R.; Zhao, Q.; Fu, D.; Gu, H.; Luo, L.; Long, H.; Zhao, Y.; Cen, X.
    Nicotinamide phosphoribosyltransferase regulates cocaine reward through sirtuin 1 (2018), Exp. Neurol., 307, 52-61 .
    View publication on PubMed
Search for more literature for 2.4.2.12

Inhibitors

Inhibitors Comment Organism Structure
FK866 specific inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Mus musculus
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q99KQ4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mus musculus nicotinamide D-ribonucleotide + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
Nampt
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme is significantly upregulated in the ventral tegmental area of cocaine-conditioned mice up

General Information

General Information Comment Organism
metabolism enzyme-mediated NAD biosynthesis may modify cocaine behavioral effects through sirtuin 1. The enzyme regulates cocaine reward through the NAD/sirtuin 1 pathway Mus musculus