Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.12 extracted from

  • Aprile, S.; Galli, U.; Tron, G.C.; Del Grosso, E.; Travelli, C.; Grosa, G.
    Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors (2020), Data Brief, 28, 105034 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.12

Inhibitors

Inhibitors Comment Organism Structure
2'-methyl-N-[7-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]heptyl][1,1'-biphenyl]-2-carboxamide
-
 Homo sapiens
2-(4-[[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]methyl]phenyl)ethyl [1,1'-biphenyl]-2-ylcarbamate
-
 Homo sapiens
2-(pyridin-3-yl)-N-[7-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]heptyl]benzamide
-
 Homo sapiens
2-bromo-N-[2-(4-[[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]methyl]phenyl)ethyl]benzene-1-sulfonamide
-
 Homo sapiens
3-(1-[6-[(2'-methyl[1,1'-biphenyl]-2-yl)oxy]hexyl]-1H-1,2,3-triazol-4-yl)pyridine
-
 Homo sapiens
3-(1-[6-[([1,1'-biphenyl]-2-yl)oxy]hexyl]-1H-1,2,3-triazol-4-yl)pyridine
-
 Homo sapiens
3-(1-[6-[2-(pyridin-3-yl)phenoxy]hexyl]-1H-1,2,3-triazol-4-yl)pyridine
-
 Homo sapiens
3-(1-[7-[([1,1'-biphenyl]-2-yl)oxy]heptyl]-1H-1,2,3-triazol-4-yl)pyridine
-
 Homo sapiens
3-(1-[7-[4-([1,1'-biphenyl]-2-yl)-1H-1,2,3-triazol-1-yl]heptyl]-1H-1,2,3-triazol-4-yl)pyridine
-
 Homo sapiens
3-(1-[8-[([1,1'-biphenyl]-2-yl)oxy]octyl]-1H-1,2,3-triazol-4-yl)pyridine
-
 Homo sapiens
3-[1-[(4-[2-[([1,1'-biphenyl]-2-yl)oxy]ethyl]phenyl)methyl]-1H-1,2,3-triazol-4-yl]pyridine
-
 Homo sapiens
6-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]hexyl [1,1'-biphenyl]-2-ylcarbamate
-
 Homo sapiens
7-(4-[[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]methyl]phenyl)heptyl [1,1'-biphenyl]-2-ylcarbamate
-
 Homo sapiens
FK866
-
 Homo sapiens
N-(4-[3-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]propyl]phenyl)[1,1'-biphenyl]-2-carboxamide
-
 Homo sapiens
N-[([1,1'-biphenyl]-2-yl)methyl]-2-(4-[[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]methyl]phenyl)ethan-1-amine
-
 Homo sapiens
N-[1,1'-biphenyl]-2-yl-N'-[2-(4-[[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]methyl]phenyl)ethyl]urea
-
 Homo sapiens
N-[1,1'-biphenyl]-2-yl-N'-[6-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]hexyl]urea
-
 Homo sapiens
N-[1,1'-biphenyl]-2-yl-N'-[7-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]heptyl]urea
-
 Homo sapiens
N-[2-(4-[[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]methyl]phenyl)ethyl][1,1'-biphenyl]-2-carboxamide
-
 Homo sapiens
N-[2-(4-[[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]methyl]phenyl)ethyl][1,1'-biphenyl]-2-sulfonamide
-
 Homo sapiens
N-[6-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]hexyl][1,1'-biphenyl]-2-carboxamide
-
 Homo sapiens
N-[7-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]heptyl][1,1'-biphenyl]-2-carboxamide
-
 Homo sapiens
N-[8-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]octyl][1,1'-biphenyl]-2-sulfonamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide D-ribonucleotide + diphosphate Homo sapiens
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide D-ribonucleotide + diphosphate
-
 Homo sapiens nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
Nampt
-
 Homo sapiens