Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FK866 | selective inhibitor | Homo sapiens | |
GMX1778 | - |
Homo sapiens | |
N-([4-(3,5-difluorobenzene-1-sulfonyl)phenyl]methyl)imidazo[1,2-a]pyridine-6-carboxamide | GNE-617 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide D-ribonucleotide + diphosphate | Homo sapiens | - |
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P43490 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide D-ribonucleotide + diphosphate | - |
Homo sapiens | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 55000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Nampt | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | reduced enzyme expression increases endothelial cell susceptibility to tumor necrosis factor-alpha-induced apoptosis as reflected by PARP-1 cleavage and caspase-3 activation | Homo sapiens |
physiological function | enzyme overexpression serves to reduce degrees of tumor necrosis factor-alpha-induced endothelial cell apoptosis | Homo sapiens |