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Literature summary for 2.4.2.12 extracted from

  • Chen, W.; Dong, G.; He, S.; Xu, T.; Wang, X.; Liu, N.; Zhang, W.; Miao, C.; Sheng, C.
    Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (2016), Bioorg. Med. Chem. Lett., 26, 765-768.
    View publication on PubMed
Search for more literature for 2.4.2.12

Inhibitors

Inhibitors Comment Organism Structure
(2E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(pyridin-3-yl)prop-2-enamide
-
 Homo sapiens
(2E)-N-[3-(1H-imidazol-1-yl)propyl]-3-(pyridin-3-yl)prop-2-enamide
-
 Homo sapiens
CHS828
-
 Homo sapiens
FK866
-
 Homo sapiens
GMX1777
-
 Homo sapiens
N-(2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-oxoethyl)-3-methylthiophene-2-carboxamide
-
 Homo sapiens
N-(2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-oxoethyl)-5-methylthiophene-2-carboxamide
-
 Homo sapiens
N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzofuran-2-carboxamide
-
 Homo sapiens
N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzothiophene-2-carboxamide
-
 Homo sapiens
N-[2-(3,4-dimethoxyphenyl)ethyl]-3-methylthiophene-2-carboxamide
-
 Homo sapiens
N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methylthiophene-2-carboxamide
-
 Homo sapiens
N-[2-(3,4-dimethoxyphenyl)ethyl]-5-nitrothiophene-2-carboxamide
-
 Homo sapiens
N-[3-(1H-imidazol-1-yl)propyl]-1-benzofuran-2-carboxamide
-
 Homo sapiens
N-[3-(1H-imidazol-1-yl)propyl]-1-benzothiophene-2-carboxamide
-
 Homo sapiens
N-[3-(1H-imidazol-1-yl)propyl]-3-methylthiophene-2-carboxamide
-
 Homo sapiens
N-[3-(1H-imidazol-1-yl)propyl]-5-methylthiophene-2-carboxamide
-
 Homo sapiens
N-[3-(1H-imidazol-1-yl)propyl]-5-nitrothiophene-2-carboxamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
Nampt
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00015
-
 pH and temperature not specified in the publication Homo sapiens N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzothiophene-2-carboxamide
0.00017
-
 pH and temperature not specified in the publication Homo sapiens N-[3-(1H-imidazol-1-yl)propyl]-5-methylthiophene-2-carboxamide
0.00086
-
 pH and temperature not specified in the publication Homo sapiens N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methylthiophene-2-carboxamide
0.00095
-
 pH and temperature not specified in the publication Homo sapiens N-(2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-oxoethyl)-5-methylthiophene-2-carboxamide
0.001
-
 pH and temperature not specified in the publication Homo sapiens N-[3-(1H-imidazol-1-yl)propyl]-1-benzofuran-2-carboxamide
0.0011
-
 pH and temperature not specified in the publication Homo sapiens N-[3-(1H-imidazol-1-yl)propyl]-1-benzothiophene-2-carboxamide
0.0014
-
 pH and temperature not specified in the publication Homo sapiens N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzofuran-2-carboxamide
0.0053
-
 pH and temperature not specified in the publication Homo sapiens N-[2-(3,4-dimethoxyphenyl)ethyl]-3-methylthiophene-2-carboxamide
0.01
-
 pH and temperature not specified in the publication Homo sapiens N-[2-(3,4-dimethoxyphenyl)ethyl]-5-nitrothiophene-2-carboxamide
0.01
-
 pH and temperature not specified in the publication Homo sapiens (2E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(pyridin-3-yl)prop-2-enamide
0.01
-
 pH and temperature not specified in the publication Homo sapiens N-(2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-oxoethyl)-3-methylthiophene-2-carboxamide
0.01
-
 pH and temperature not specified in the publication Homo sapiens N-[3-(1H-imidazol-1-yl)propyl]-3-methylthiophene-2-carboxamide
0.01
-
 pH and temperature not specified in the publication Homo sapiens N-[3-(1H-imidazol-1-yl)propyl]-5-nitrothiophene-2-carboxamide
0.01
-
 pH and temperature not specified in the publication Homo sapiens (2E)-N-[3-(1H-imidazol-1-yl)propyl]-3-(pyridin-3-yl)prop-2-enamide