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Literature summary for 2.4.2.12 extracted from

  • Zhang, L.Q.; Heruth, D.P.; Ye, S.Q.
    Nicotinamide phosphoribosyltransferase in human diseases (2011), J. Bioanal. Biomed., 3, 13-25.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.12

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
H247A active site residue, no detectable activity Homo sapiens
H247E active site residue, low activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
FK-866 i.e. (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-phenylprop-2-enamide Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55520
-
 2 * 55520, theoretic value Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation can increase the activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
lymphocyte
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phosphoribosyl 1-diphosphate
-
 Homo sapiens nicotinamide mononucleotide + diphosphate
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 55520, theoretic value Homo sapiens

Synonyms

Synonyms Comment Organism
nicotinamide phosphoribosyltransferase
-
 Homo sapiens
pre-B-cell colony enhancing factor
-
 Homo sapiens
Visfatin
-
 Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens theoretic value
-
 6.69

General Information

General Information Comment Organism
malfunction implicated in the pathogenesis of a number of human diseases or conditions such as acute lung injury, aging, atherosclerosis, cancer, diabetes, rheumatoid arthritis and sepsis Homo sapiens
physiological function growth factor, cytokine and nicotinamide phosphoribosyltransferase Homo sapiens