Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mus musculus |
expression in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystal structures at up to 2.1 A resolution of NMPRTase, alone and in complex with the reaction product nicotinamide mononucleotide or the inhibitor FK866. Crystals of the selenomethionyl free enzyme of human NMPRTase (F132M I151M double mutant) are grown with the sitting drop vapor diffusion method at 22°C. Crystals of wild-type human NMPRTase in complex with NMN are obtained at 22°C by sitting drop vapor diffusion | Homo sapiens |
crystal structures at up to 2.1 A resolution of NMPRTase, alone and in complex with the reaction product nicotinamide mononucleotide or the inhibitor FK866. Crystals of wild-type murine NMPRTase free enzyme are obtained by sitting drop vapor diffusion at 4°C | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FK866 | FK866 is bound in a tunnel at the interface of the NMPRTase dimer, the inhibitor can reduce cellular NAD+ levels and induce apoptosis in tumors | Homo sapiens | |
FK866 | FK866 is bound in a tunnel at the interface of the NMPRTase dimer, the inhibitor can reduce cellular NAD+ levels and induce apoptosis in tumors | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | NMPRTase is a crucial enzyme in the salvage pathway of NAD+ biosynthesis and has important functions in regulating NAD+ levels in cells undergoing substantial NAD+ turnover | ? | - |
? | |
additional information | Homo sapiens | NMPRTase is a crucial enzyme in the salvage pathway of NAD+ biosynthesis and has important functions in regulating NAD+ levels in cells undergoing substantial NAD+ turnover | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P43490 | - |
- |
Mus musculus | Q99KQ4 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | NMPRTase is a crucial enzyme in the salvage pathway of NAD+ biosynthesis and has important functions in regulating NAD+ levels in cells undergoing substantial NAD+ turnover | Mus musculus | ? | - |
? | |
additional information | NMPRTase is a crucial enzyme in the salvage pathway of NAD+ biosynthesis and has important functions in regulating NAD+ levels in cells undergoing substantial NAD+ turnover | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NMPRTase | - |
Mus musculus |
NMPRTase | - |
Homo sapiens |