BRENDA - Enzyme Database show
show all sequences of 2.4.2.12

Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis

Rongvaux, A.; Shea, R.J.; Mulks, M.H.; Gigot, D.; Urbain, J.; Leo, O.; Andris, F.; Eur. J. Immunol. 32, 3225-3234 (2002)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
pre-B-cell colony enhancing factor
Mus musculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00124
-
nicotinamide
-
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Mus musculus
5737
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Mus musculus
pre-B-cell colony enhancing factor
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
identified as pre-B-cell colony-enhancing factor
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
lymphocyte
-
Mus musculus
-
additional information
ubiquitous in all tissues
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
489743
Mus musculus
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
pre-B-cell colony enhancing factor
489743
Mus musculus
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
pre-B-cell colony enhancing factor
Mus musculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00124
-
nicotinamide
-
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Mus musculus
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Mus musculus
pre-B-cell colony enhancing factor
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
lymphocyte
-
Mus musculus
-
additional information
ubiquitous in all tissues
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
489743
Mus musculus
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
pre-B-cell colony enhancing factor
489743
Mus musculus
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
Other publictions for EC 2.4.2.12
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735765
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Application of virtual screeni ...
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2920-2926
2016
-
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-
-
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17
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1
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2
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1
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13
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13
17
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1
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1
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-
-
-
-
735766
Chen
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Bioorg. Med. Chem. Lett.
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-
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-
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-
17
-
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1
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2
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1
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14
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14
17
-
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1
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735872
Grolla
Extracellular nicotinamide pho ...
Homo sapiens
Br. J. Pharmacol.
173
2182-2194
2016
-
-
-
-
14
-
1
-
1
-
-
1
-
1
-
-
-
-
-
49
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
14
-
-
1
-
-
1
-
-
1
-
-
-
-
-
49
-
-
1
-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
736091
Fang
Analysis of the nicotinamide p ...
Danio rerio
FEBS J.
282
2858-2878
2015
-
-
-
-
-
-
-
-
-
-
1
1
-
3
-
-
-
-
-
1
-
-
1
-
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-
-
-
-
-
-
-
-
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-
1
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
736115
Marletta
Crystal structure of human nic ...
Homo sapiens
FEBS Open Bio
5
419-428
2015
-
-
-
-
-
-
1
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
737247
Xu
Discovery and characterization ...
Homo sapiens
Sci. Rep.
5
10043
2015
-
-
-
-
-
-
49
-
-
-
1
1
-
2
-
-
-
-
-
4
-
-
1
1
-
-
-
-
-
-
-
-
-
-
48
-
-
-
-
-
-
-
48
49
-
-
-
-
1
1
-
-
-
-
-
4
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737279
Zabka
Retinal toxicity, in vivo and ...
Homo sapiens, Rattus norvegicus
Toxicol. Sci.
144
163-172
2015
-
-
-
-
-
-
14
-
-
-
-
2
-
7
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
14
-
-
-
-
-
2
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735760
Zheng
Discovery of potent and effica ...
Homo sapiens
Bioorg. Med. Chem. Lett.
24
337-343
2014
-
-
-
-
-
-
18
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
14
-
-
-
-
-
-
-
14
18
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
736003
Hsu
The function of nicotinamide p ...
Homo sapiens
DNA Repair
23
64-68
2014
-
-
1
-
-
-
1
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
736227
Pittelli
Nicotinamide phosphoribosyltra ...
Homo sapiens, Mus musculus
Immunol. Cell Biol.
92
191-199
2014
-
-
-
-
-
-
2
-
-
-
-
2
-
4
-
-
-
-
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2
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2
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2
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2
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2
-
-
2
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
735758
Zheng
Identification of amides deriv ...
Homo sapiens
Bioorg. Med. Chem. Lett.
23
5488-5497
2013
-
-
-
-
-
-
32
-
-
-
-
1
-
6
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
28
-
-
-
-
-
-
-
28
32
-
-
-
-
-
1
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
736436
Tan
Pharmacological inhibition of ...
Homo sapiens
J. Biol. Chem.
288
3500-3511
2013
-
-
-
-
-
-
1
-
-
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1
-
2
-
-
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-
-
12
-
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1
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1
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1
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-
-
12
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
736612
Zheng
Structure-based discovery of n ...
Homo sapiens
J. Med. Chem.
56
6413-6433
2013
-
-
-
-
-
-
40
-
-
-
-
1
-
2
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
-
-
-
35
-
-
-
-
-
-
-
35
40
-
-
-
-
-
1
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723576
Bowlby
Nicotinamide phosphoribosyl tr ...
Homo sapiens
PLoS ONE
7
e40195
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
5
-
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-
-
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-
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-
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-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
723588
Liu
Nicotinamide phosphoribosyltra ...
Mus musculus
PLoS ONE
7
e44933
2012
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
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1
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-
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-
-
-
-
-
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-
1
-
-
1
-
-
721273
Zhang
A fluorometric assay for high- ...
Mus musculus
Anal. Biochem.
412
18-25
2011
-
-
1
-
-
-
4
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
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-
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-
-
-
-
-
4
-
-
1
-
-
-
-
4
4
-
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-
-
-
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-
1
-
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-
1
-
-
-
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-
-
-
-
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-
-
722099
Friebe
Leucocytes are a major source ...
Homo sapiens
Diabetologia
54
1200-1211
2011
-
-
-
-
-
-
-
-
-
-
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2
-
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2
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2
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722182
Dahl
Nicotinamide phosphoribosyltra ...
Homo sapiens
Eur. J. Clin. Invest.
41
1098-1104
2011
-
-
-
-
-
-
1
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1
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1
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1
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1
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1
-
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1
-
-
722560
Zhang
Nicotinamide phosphoribosyltra ...
Homo sapiens
J. Bioanal. Biomed.
3
13-25
2011
-
-
1
-
2
-
1
-
-
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1
-
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2
-
1
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9
-
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1
1
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1
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1
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2
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1
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1
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1
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9
-
-
1
1
-
-
-
-
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1
-
2
2
-
-
-
722718
Hong
Nicotinamide phosphoribosyltra ...
Oryctolagus cuniculus
J. Biol. Chem.
286
28619-28631
2011
-
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1
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1
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1
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723535
Hara
Nicotinamide phosphoribosyltra ...
Homo sapiens
PLoS ONE
6
e22781
2011
1
-
1
-
-
-
-
4
-
-
-
-
-
3
-
-
-
-
-
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7
-
1
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1
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1
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4
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7
-
1
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702085
Garten
Nicotinamide phosphoribosyltra ...
Homo sapiens
Biochem. Biophys. Res. Commun.
391
376-381
2010
-
-
-
-
-
-
-
-
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2
-
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3
-
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3
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2
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2
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3
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2
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-
704364
Takahashi
Structure and reaction mechani ...
Homo sapiens
J. Biochem.
147
95-107
2010
-
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-
1
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2
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1
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1
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1
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705072
Colombano
A novel potent nicotinamide ph ...
Homo sapiens
J. Med. Chem.
53
616-623
2010
-
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-
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-
1
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1
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1
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