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Literature summary for 2.4.2.10 extracted from
- Ground-state destabilization in orotate phosphoribosyltransferases by binding isotope effects (2011), Biochemistry, 50, 4813-4818.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Homo sapiens |
| expressed in Escherichia coli | Plasmodium falciparum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sulfate | competitive to diphosphate | Homo sapiens |  |
| sulfate | competitive to diphosphate | Plasmodium falciparum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0016 | - |
orotidine 5'-phosphate | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.0037 | - |
orotidine 5'-phosphate | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 0.091 | - |
Orotidine | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 0.096 | - |
Orotidine | pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Plasmodium falciparum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Plasmodium falciparum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| orotidine + diphosphate | - |
Homo sapiens | orotate + alpha-D-ribose 1-diphosphate | - |
r | |
| orotidine + diphosphate | - |
Plasmodium falciparum | orotate + alpha-D-ribose 1-diphosphate | - |
r | |
| orotidine 5'-phosphate + diphosphate | - |
Homo sapiens | orotate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
| orotidine 5'-phosphate + diphosphate | - |
Plasmodium falciparum | orotate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| orotate phosphoribosyltransferase | - |
Homo sapiens |
| orotate phosphoribosyltransferase | - |
Plasmodium falciparum |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.7 | - |
sulfate | orotidine 5'-phosphate as substrate, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 3.1 | - |
sulfate | orotidine 5'-phosphate as substrate, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
| 10.8 | - |
sulfate | orotidine 5'-phosphate as substrate, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
| 17.6 | - |
sulfate | orotidine 5'-phosphate as substrate, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
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