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Literature summary for 2.4.2.10 extracted from

  • Matsusaka, S.; Yamasaki, H.; Fukushima, M.; Wakabayashi, I.
    Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer (2007), Chemotherapy, 53, 36-41.
    View publication on PubMed
Search for more literature for 2.4.2.10

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens the enzyme is involved in the metabolism of 5-fluorouracil, a chemotherapeutic drug in treatment of solid cancers, major pathways of 5-fluorouracil metabolism, overview 5-fluorouridine 5'-phosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information the enzyme expression is increased in tumor tissue compared to non-tumor tissue Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
 ?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate the enzyme is involved in the metabolism of 5-fluorouracil, a chemotherapeutic drug in treatment of solid cancers, major pathways of 5-fluorouracil metabolism, overview Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
OPRT
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Homo sapiens