Literature summary for 2.4.2.10 extracted from

Mizutani, Y.; Wada, H.; Fukushima, M.; Yoshida, O.; Nakanishi, H.; Li, Y.N.; Miki, T.
Prognostic significance of orotate phosphoribosyltransferase activity in bladder carcinoma (2004), Cancer, 100, 723-731.

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Application

Application	Comment	Organism
medicine	enzyme activity is 7.5fold enhanced in bladder carcinoma compared to normal. Bladder carcinoma subtypes show distinct levels of enzyme activity and there is positive association between the activity levels of enzyme and thymidylate synthase/thymidine kinase. Enzyme activity in bladder carcinoma cells also correlates positively with their sensitivity to 5-fluorouracil	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with bladder carcinoma	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bladder	-	Homo sapiens	-

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Release 2023.1 (January 2023)