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Literature summary for 2.4.1.B80 extracted from

  • Inamori, K.; Hara, Y.; Willer, T.; Anderson, M.E.; Zhu, Z.; Yoshida-Moriguchi, T.; Campbell, K.P.
    Xylosyl- and glucuronyltransferase functions of LARGE in alpha-dystroglycan modification are conserved in LARGE2 (2013), Glycobiology, 23, 295-302 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.B80

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information expression of a secreted form that lack the transmembrane domain Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q5XPT3 isoform LARGE2
-
Mus musculus Q9Z1M7 isoform LARGE1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is specific for the transfer of D-xylose and D-glucuronate. The enzyme is capable of synthesizing [3-alpha-D-xylosyl-(1->3)-beta-D-glucuronyl-1-] repeats Mus musculus ?
-
-
UDP-alpha-D-glucuronate + 4-methylumbelliferyl alpha-D-xylosyl-(1->3)-beta-D-glucuronate
-
 Mus musculus UDP + 4-methylumbelliferyl beta-D-glucuronosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucuronate
-
 ?
UDP-alpha-D-glucuronate + 4-nitrophenyl alpha-D-xyloside
-
 Mus musculus UDP + 4-nitrophenyl beta-D-glucuronyl-(1->3)-alpha-D-xyloside
-
 ?
UDP-alpha-D-xylose + 4-methylumbelliferyl beta-D-glucuronate
-
 Mus musculus UDP + 4-methylumbelliferyl alpha-D-xylosyl-(1->3)-beta-D-glucuronate
-
 ?

Synonyms

Synonyms Comment Organism
LARGE1
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
 xylosyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus
5.5
-
 glucuronyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus
5.5 8 glucuronyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus
5.5 9 xylosyltransferase activity, recombinant protein lacking the transmembrane domain Mus musculus