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Literature summary for 2.4.1.B62 extracted from

  • Genth, H.; Pauillac, S.; Schelle, I.; Bouvet, P.; Bouchier, C.; Varela-Chavez, C.; Just, I.; Popoff, M.R.
    Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins (2014), Cell. Microbiol., 16, 1706-1721.
    View publication on PubMed
Search for more literature for 2.4.1.B62

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Paeniclostridium sordellii

Organism

Organism UniProt Comment Textmining
Paeniclostridium sordellii M9ZTT7
-
-
Paeniclostridium sordellii V5T923
-
-
Paeniclostridium sordellii vpi9048 M9ZTT7
-
-
Paeniclostridium sordellii vpi9048 V5T923
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information full-length hemorrhagic toxin TcsH exclusively glucosylates Rho-GTPases. The recombinant transferase domain glucosylates preferably Rho-GTPases but also Ras-GTPases to some extent. Vero cells treated with full length TcsH also show glucosylation of Ras, albeit to a lower extent than of Rho-GTPases Paeniclostridium sordellii ?
-
 ?
additional information full-length hemorrhagic toxin TcsH exclusively glucosylates Rho-GTPases. The recombinant transferase domain glucosylates preferably Rho-GTPases but also Ras-GTPases to some extent. Vero cells treated with full length TcsH also show glucosylation of Ras, albeit to a lower extent than of Rho-GTPases Paeniclostridium sordellii vpi9048 ?
-
 ?
UDP-alpha-D-glucose + Cdc42
-
 Paeniclostridium sordellii UDP + D-glucosyl-Cdc42
-
 ?
UDP-alpha-D-glucose + Cdc42
-
 Paeniclostridium sordellii vpi9048 UDP + D-glucosyl-Cdc42
-
 ?
UDP-alpha-D-glucose + H-Ras good substrate Paeniclostridium sordellii UDP + D-glucosyl-H-Ras
-
 ?
UDP-alpha-D-glucose + H-Ras good substrate Paeniclostridium sordellii vpi9048 UDP + D-glucosyl-H-Ras
-
 ?
UDP-alpha-D-glucose + K-Ras good substrate Paeniclostridium sordellii UDP + D-glucosyl-K-Ras
-
 ?
UDP-alpha-D-glucose + N-Ras good substrate Paeniclostridium sordellii UDP + D-glucosyl-N-Ras
-
 ?
UDP-alpha-D-glucose + Rac1 very good substrate Paeniclostridium sordellii UDP + D-glucosyl-Rac1
-
 ?
UDP-alpha-D-glucose + Rac1 very good substrate Paeniclostridium sordellii vpi9048 UDP + D-glucosyl-Rac1
-
 ?
UDP-alpha-D-glucose + RalC good substrate Paeniclostridium sordellii UDP + D-glucosyl-RalC
-
 ?
UDP-alpha-D-glucose + Rap2A good substrate Paeniclostridium sordellii UDP + D-glucosyl-Rap2A
-
 ?
UDP-alpha-D-glucose + Rap2A good substrate Paeniclostridium sordellii vpi9048 UDP + D-glucosyl-Rap2A
-
 ?
UDP-alpha-D-glucose + RhoA
-
 Paeniclostridium sordellii UDP + D-glucosyl-RhoA
-
 ?
UDP-alpha-D-glucose + RhoA
-
 Paeniclostridium sordellii vpi9048 UDP + D-glucosyl-RhoA
-
 ?
UDP-alpha-D-glucose + RhoB
-
 Paeniclostridium sordellii UDP + D-glucosyl-Rhob
-
 ?
UDP-alpha-D-glucose + RhoC
-
 Paeniclostridium sordellii UDP + D-glucosyl-RhoC
-
 ?
UDP-alpha-D-glucose + RhoG
-
 Paeniclostridium sordellii UDP + D-glucosyl-RhoG
-
 ?
UDP-alpha-D-glucose + TC10 good substrate Paeniclostridium sordellii UDP + D-glucosyl-TC10
-
 ?
UDP-alpha-D-glucose + TCL signaling G protein good substrate Paeniclostridium sordellii UDP + D-glucosyl-TCL signaling G protein
-
 ?

Synonyms

Synonyms Comment Organism
cytotoxin L
-
 Paeniclostridium sordellii
haemorrhagic toxin
-
 Paeniclostridium sordellii
hemorrhagic toxin
-
 Paeniclostridium sordellii
letal toxin
-
 Paeniclostridium sordellii
TcsH
-
 Paeniclostridium sordellii
TcsL
-
 Paeniclostridium sordellii

General Information

General Information Comment Organism
physiological function full-length hemorrhagic toxin TcsH exclusively glucosylates Rho-GTPases. The recombinant transferase domain glucosylates preferably Rho-GTPases but also Ras-GTPases to some extent. Vero cells treated with full length TcsH also show glucosylation of Ras, albeit to a lower extent than of Rho-GTPases. In addition, enzyme induces a rapid dephosphorylation of pY118-paxillin and of pS144/141-PAK1/2 prior to actin filament depolymerization Paeniclostridium sordellii